CAS 15345-89-8|Desmethoxyyangonin

Introduction：Basic information about CAS 15345-89-8|Desmethoxyyangonin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Desmethoxyyangonin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles7
7. Synonyms

Common Name	Desmethoxyyangonin
CAS Number	15345-89-8	Molecular Weight	228.243
Density	1.2±0.1 g/cm3	Boiling Point	440.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₂O₃	Melting Point	138-140ºC
MSDS	ChineseUSA	Flash Point	188.0±23.3 °C

Names

Name	Desmethoxy Yangonin
Synonym	More Synonyms

Desmethoxyyangonin BiologicalActivity

Description	Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>OthersNatural Products >>Others
References	[1]. Uebelhack R, et al. Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). Pharmacopsychiatry. 1998 Sep;31(5):187-92. [2]. Baum SS, et al. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22(7):1105-20. [3]. Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32(11):1317-24.

Description

Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.

Related Catalog

Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>OthersNatural Products >>Others

References

[1]. Uebelhack R, et al. Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). Pharmacopsychiatry. 1998 Sep;31(5):187-92.

[2]. Baum SS, et al. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22(7):1105-20.

[3]. Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32(11):1317-24.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	440.0±45.0 °C at 760 mmHg
Melting Point	138-140ºC
Molecular Formula	C₁₄H₁₂O₃
Molecular Weight	228.243
Flash Point	188.0±23.3 °C
Exact Mass	228.078644
PSA	39.44000
LogP	1.80
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.588
InChIKey	DKKJNZYHGRUXBS-BQYQJAHWSA-N
SMILES	COc1cc(C=Cc2ccccc2)oc(=O)c1
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ1240000

CHEMICAL NAME :: 2H-Pyran-2-one, 4-methoxy-6-styryl-, (E)-

CAS REGISTRY NUMBER :: 15345-89-8

LAST UPDATED :: 199206

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H12-O3

MOLECULAR WEIGHT :: 228.26

WISWESSER LINE NOTATION :: T6OVJ DO1 F1U1R DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

Safety Information

RIDADR	NONH for all modes of transport

Articles7

Fatal kavalactone intoxication by suicidal intravenous injection.

Forensic Sci. Int. 249 , e7-11, (2015)

Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxioly...

Contribution to the quantitative and enantioselective determination of kavapyrones by high-performance liquid chromatography on ChiraSpher NT material.

J. Chromatogr. B. Biomed. Sci. Appl. 702(1-2) , 240-4, (1997)

A simultaneous HPLC separation of the enantiomers of kavain, dihydrokavain, methysticin and dihydromethysticin, as well as the achiral dienolides yangonin and desmethoxyyangonin was carried out on a C...

[Effects of the constituents of Alpinia speciosa rhizoma on experimental ulcers].

Taiwan Yi Xue Hui Za Zhi. 86(1) , 58-64, (1987)

Synonyms

DIHYDROKAVAIN

2H-Pyran-2-one, 4-methoxy-6-(2-phenylethenyl)-

2H-Pyran-2-one, 4-methoxy-6-[(E)-2-phenylethenyl]-

4-Methoxy-6-[(E)-2-phenylvinyl]-2H-pyran-2-one

4-methoxy-6-[(E)-2-phenylethenyl]-2H-pyran-2-one

Desmethoxyyangonin

(E)-4-Methoxy-6-(2-phenylethenyl)-2H-pyran-2-one,5,6-Dehydrokavain,Demethoxyyangonin

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