CAS 700-49-2|TCMDC-124283
Introduction：Basic information about CAS 700-49-2|TCMDC-124283, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | TCMDC-124283 | ||
|---|---|---|---|
| CAS Number | 700-49-2 | Molecular Weight | 153.12 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 676.9±58.0 °C at 760 mmHg |
| Molecular Formula | C5H4FN5 | Melting Point | >350 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 363.2±32.3 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-fluoroadenine |
|---|---|
| Synonym | More Synonyms |
TCMDC-124283 BiologicalActivity
| Description | 2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis |
| Target | DNA/RNA synthesis[1] |
| In Vitro | 2-Fluoroadenine (2 μM; 4 hours) inhibits CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis[1]. 2-Fluoroadenine (0-1000 μM; 96 hours) exhibits cytotoxicity in nonproliferating MRC-5 cells[1]. 2-Fluoroadenine (0.22, 2.2 and 22 μM; 30 hours) inhibits protein, RNA, and DNA syntheses in Balb-3T3 cells incubated in serum-free medium[1]. Cell Proliferation Assay Cell Line: CEM cells[1] Concentration: 2 μM Incubation Time: 4 hours Result: Inhibited CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis. Cell Cytotoxicity Assay Cell Line: MRC-5 cells[1] Concentration: 0-1000 μM Incubation Time: 4 hours Result: Exhibited cytotoxicity in nonproliferating MRC-5 cells. |
| References | [1]. Parker WB, et al. Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells. Biochem Pharmacol. 1998;55(10):1673-1681. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 676.9±58.0 °C at 760 mmHg |
| Melting Point | >350 °C(lit.) |
| Molecular Formula | C5H4FN5 |
| Molecular Weight | 153.12 |
| Flash Point | 363.2±32.3 °C |
| Exact Mass | 153.045074 |
| PSA | 80.48000 |
| LogP | -0.01 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.783 |
| InChIKey | WKMPTBDYDNUJLF-UHFFFAOYSA-N |
| SMILES | Nc1nc(F)nc2nc[nH]c12 |
| Storage condition | Refrigerator |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11340 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AU6264700 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles17
More Articles| Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line. BMC Cancer 14 , 547, (2014) Nine-beta-D-arabinofuranosylguanine (ara-G), an active metabolite of nelarabine, enters leukemic cells through human Equilibrative Nucleoside Transporter 1, and is then phosphorylated to an intracellu... | |
| Endothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor. PLoS ONE 9(6) , e98818, (2014) The endothelin axis, comprising endothelins (ET-1, ET-2 and ET-3) and their receptors (ET(A)R and ETBR), has emerged as relevant player in tumor growth and metastasis. Here, we investigated the involv... | |
| Preparation of a fludarabine intermediate via selective alkylation of 2-fluoroadenine. Nucleosides Nucleotides Nucleic Acids 25(7) , 735-45, (2006) The reaction between 2-fluoroadenine (3) and 1,3,5-tri-O-benzyl-1-alpha-D-chloroarabinofuranose (4) with potassium t-amylate was evaluated in various solvents to afford 9-beta-D-(2,3,5-tri-O-benzyl-ar... |
Synonyms
| 2-fluoro-adenin |
| 2-FLUORO-6-AMINOPURINE |
| 7H-Purin-6-amine, 2-fluoro- |
| 2-fluoro-9H-purin-6-amine |
| 2-Fluoroadenine |
| 6-AMINO-2-FLUOROPURINE |
| TCMDC-124283 |
| MFCD01632749 |
| 2-fluoropurine |
| 2-fluoroadenibe |
| 2-Fluoro-1H-purin-6-amine |
| 2-fad |
| 6-amino-2-fluoro-purin |
| BUTTPARK 25 1-01 |
| 2-fluoradenine |
| 2-fluoro-1h-purin-6-amin |
