Introduction：Basic information about CAS 85643-19-2|Curculigoside, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Curculigoside |
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| CAS Number | 85643-19-2 | Molecular Weight | 466.435 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 734.9±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H26O11 | Melting Point | 158-160ºC |
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| MSDS | / | Flash Point | 253.8±26.4 °C |
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Names
| Name | curculigoside |
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| Synonym | More Synonyms |
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Curculigoside BiologicalActivity
| Description | Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway[1]. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>STATSignaling Pathways >>JAK/STAT Signaling >>JAKSignaling Pathways >>Epigenetics >>JAKSignaling Pathways >>Stem Cell/Wnt >>JAKSignaling Pathways >>JAK/STAT Signaling >>STATResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
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| Target | JAK; STAT; NF-κB[1] |
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| In Vitro | Curculigoside (1-64 μg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability between 1 and 64 µg/ml in MH7A cells[1]. Curculigoside (4-16 μg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-α group[1]. Cell Viability Assay[1] Cell Line: MH7A cells Concentration: 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml Incubation Time: 72 hours Result: Had inhibitory effect on MH7A cells. Western Blot Analysis[1] Cell Line: MH7A cells Concentration: 4 μg/ml; 64 μg/ml Incubation Time: 24 hours Result: Downregulated JAK1, JAK3 and STAT3 protein expression. |
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| References | [1]. Tan S, et al. Curculigoside exerts significant anti arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF κB signaling pathway. Mol Med Rep. 2019 Mar;19(3):2057-2064. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 734.9±60.0 °C at 760 mmHg |
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| Melting Point | 158-160ºC |
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| Molecular Formula | C22H26O11 |
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| Molecular Weight | 466.435 |
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| Flash Point | 253.8±26.4 °C |
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| Exact Mass | 466.147522 |
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| PSA | 164.37000 |
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| LogP | -0.02 |
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| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
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| Index of Refraction | 1.624 |
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| InChIKey | SJJRKHVKAXVFJQ-QKYBYQKWSA-N |
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| SMILES | COc1cccc(OC)c1C(=O)OCc1cc(O)ccc1OC1OC(CO)C(O)C(O)C1O |
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Safety Information
| Safety Phrases | 24/25 |
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| HS Code | 29389090 |
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Synonyms
| β-D-Glucopyranoside, 2-(((2,6-dimethoxybenzoyl)oxy)methyl)-4-hydroxyphenyl |
| Curculigoside A |
| 2-(β-D-Glucopyranosyloxy)-5-hydroxybenzyl 2,6-dimethoxybenzoate |
| Benzoic acid, 2,6-dimethoxy-, [2-(β-D-glucopyranosyloxy)-5-hydroxyphenyl]methyl ester |
