Introduction：Basic information about CAS 5949-11-1|Cinchonine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cinchonine hydrochloride |
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| CAS Number | 5949-11-1 | Molecular Weight | 330.852 |
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| Density | / | Boiling Point | 464.5ºC at 760 mmHg |
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| Molecular Formula | C19H23ClN2O | Melting Point | 208-218ºC(lit.) |
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| MSDS | / | Flash Point | / |
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Names
| Name | Cinchonine monohydrochloride hydrate |
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| Synonym | More Synonyms |
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Cinchonine hydrochloride BiologicalActivity
| Description | Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural compound present in Cinchona bark. Cinchonine hydrochloride activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| References | [1]. Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050. |
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Chemical & Physical Properties
| Boiling Point | 464.5ºC at 760 mmHg |
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| Melting Point | 208-218ºC(lit.) |
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| Molecular Formula | C19H23ClN2O |
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| Molecular Weight | 330.852 |
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| Exact Mass | 330.149902 |
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| PSA | 36.36000 |
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| LogP | 3.90450 |
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| InChIKey | IMUHWLVEEVGMBC-ITZVBHCYSA-N |
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| SMILES | C=CC1CN2CCC1CC2C(O)c1ccnc2ccccc12.Cl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- GD2962020
- CHEMICAL NAME :
- Cinchonan-9-ol, monohydrochloride, (9S)-
- CAS REGISTRY NUMBER :
- 5949-11-1
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C19-H22-N2-O.Cl-H
- MOLECULAR WEIGHT :
- 330.89
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 720 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2550093
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992
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Safety Information
| Hazard Codes | Xi,Xn |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | 36/37-26 |
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| RIDADR | UN 1544 |
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| WGK Germany | 3 |
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| RTECS | GD2962020 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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Synonyms
| Cinchonan-9-ol, (9S)-, hydrochloride (1:1) |
| Cinchonan-9-ol, hydrochloride, (9S)- |
| Hydrogen chloride (9S)-cinchonan-9-ol (1:1:1) |
| cinchonan-9-ol,monohydrochloride, (9s)- |
| cinchonine hydrochloride hydrate |
| cinchonine hydrochloride dihydrate |
| cinchonine hydrochloride |
| cinchodinine dihydrochloride |
| cinchonine monohydrochloride dihydrate |
| cinchonine hydrochloride, hydrate |
| Cinchonan-9-ol, chloride, hydrogen salt, (9S)- (1:1) |
| l-cinchonine hydrochloride |
