CAS 99291-25-5|Levodropropizine

Introduction：Basic information about CAS 99291-25-5|Levodropropizine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Levodropropizine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles25
8. Synonyms

Common Name	Levodropropizine
CAS Number	99291-25-5	Molecular Weight	236.310
Density	1.2±0.1 g/cm3	Boiling Point	412.7±34.0 °C at 760 mmHg
Molecular Formula	C₁₃H₂₀N₂O₂	Melting Point	102-106ºC
MSDS	/	Flash Point	220.9±24.3 °C

Names

Name	levodropropizine
Synonym	More Synonyms

Levodropropizine BiologicalActivity

Description	Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Histamine ReceptorSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Inflammation/Immunology
References	[1]. Zanasi A, et al. Levodropropizine for treating cough in adult and children: a meta-analysis of published studies. Multidiscip Respir Med. 2015 May 31;10(1):19.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	412.7±34.0 °C at 760 mmHg
Melting Point	102-106ºC
Molecular Formula	C₁₃H₂₀N₂O₂
Molecular Weight	236.310
Flash Point	220.9±24.3 °C
Exact Mass	236.152481
PSA	46.94000
LogP	0.46
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.577
InChIKey	PTVWPYVOOKLBCG-ZDUSSCGKSA-N
SMILES	OCC(O)CN1CCN(c2ccccc2)CC1
Storage condition	Refrigerator

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ1075100

CHEMICAL NAME :: 1,2-Propanediol, 3-(4-phenylpiperazin-1-yl)-, S(-)-

CAS REGISTRY NUMBER :: 99291-25-5

LAST UPDATED :: 199609

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H20-N2-O2

MOLECULAR WEIGHT :: 236.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 887 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 401 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1281 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 408 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2493 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988

Safety Information

HS Code	2933599090

Customs

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles25

Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough.

J. Int. Med. Res. 23(3) , 175-83, (1995)

The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 were evaluable for tolerability and 254 for e...

Efficacy of levodropropizine in pediatric cough.

Pulm. Pharmacol. Ther. 25(5) , 337-42, (2012)

Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respir...

Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.

Ther. Drug Monit. 26(4) , 441-9, (2004)

Studies are described on the metabolism and the toxicologic analysis of the nonopioid cough suppressant dropropizine [R,S-3-(4-phenyl-1-piperazinyl)1,2-propandiol, DRO] in human urine using gas chroma...

Synonyms

(S)-dropropizine

Levdropropizina

1,2-Propanediol,3-(4-phenyl-1-piperazinyl)-,(R)

(-)-Dropropizine

rapitux

1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-, (2S)-

(+)-Dropropizine

(2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

(R)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol

Levdropropizina [Latin,Spanish]

(2S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol

(R)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol

Levodropropizine

Dropropizine S-form

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