CAS 142340-99-6|Adefovir Dipivoxil

Introduction：Basic information about CAS 142340-99-6|Adefovir Dipivoxil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Adefovir Dipivoxil BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles37
6. Synonyms

Common Name	Adefovir Dipivoxil
CAS Number	142340-99-6	Molecular Weight	501.470
Density	1.4±0.1 g/cm3	Boiling Point	641.0±65.0 °C at 760 mmHg
Molecular Formula	C₂₀H₃₂N₅O₈P	Melting Point	98-102ºC
MSDS	ChineseUSA	Flash Point	341.5±34.3 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	Adefovir dipivoxil
Synonym	More Synonyms

Adefovir Dipivoxil BiologicalActivity

Description	Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.Target: NRTIs; HBVAdefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4].
Related Catalog	Signaling Pathways >>Anti-infection >>HBVSignaling Pathways >>Anti-infection >>Reverse TranscriptaseResearch Areas >>Infection
References	[1]. Marcellin, P., et al., Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med, 2003. 348(9): p. 808-16. [2]. Manolakopoulos, S., et al., Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine. Aliment Pharmacol Ther, 2008. 27(3): p. 266-73. [3]. Committee, A.I.S., A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial. HIV Med, 2002. 3(4): p. 229-38. [4]. Fisher, E.J., et al., The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. AIDS, 2001. 15(13): p. 1695-700.

Description

Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.Target: NRTIs; HBVAdefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4].

Related Catalog

Signaling Pathways >>Anti-infection >>HBVSignaling Pathways >>Anti-infection >>Reverse TranscriptaseResearch Areas >>Infection

References

[1]. Marcellin, P., et al., Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med, 2003. 348(9): p. 808-16.

[2]. Manolakopoulos, S., et al., Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine. Aliment Pharmacol Ther, 2008. 27(3): p. 266-73.

[3]. Committee, A.I.S., A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial. HIV Med, 2002. 3(4): p. 229-38.

[4]. Fisher, E.J., et al., The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. AIDS, 2001. 15(13): p. 1695-700.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	641.0±65.0 °C at 760 mmHg
Melting Point	98-102ºC
Molecular Formula	C₂₀H₃₂N₅O₈P
Molecular Weight	501.470
Flash Point	341.5±34.3 °C
Exact Mass	501.198853
PSA	176.79000
LogP	2.45
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.569
InChIKey	WOZSCQDILHKSGG-UHFFFAOYSA-N
SMILES	CC(C)(C)C(=O)OCOP(=O)(COCCn1cnc2c(N)ncnc21)OCOC(=O)C(C)(C)C
Storage condition	−20°C

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R20/21/22
Safety Phrases	36/37
RIDADR	NONH for all modes of transport

Articles37

Modulating the dehydration conditions of adefovir dipivoxil dihydrate to obtain different physical forms of anhydrate.

J. Pharm. Sci. 104(3) , 1056-64, (2015)

The physical form of anhydrous adefovir dipivoxil (AD), obtained following the dehydration of AD dihydrate, was governed by the kinetics of water removal. The rate and extent of water removal followin...

De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis.

World J. Gastroenterol. 19(37) , 6278-83, (2013)

To compare efficacy of combined lamivudine (LAM) and adefovir dipivoxil (ADV) therapy with that of entecavir (ETV) monotherapy for hepatitis B virus (HBV)-related decompensated liver cirrhosis.A total...

Discovering novel direct acting antiviral agents for HBV using in silico screening.

Biochem. Biophys. Res. Commun. 456(1) , 20-8, (2015)

The treatments for chronic hepatitis B (CHB) are interferon and nucleoside analogues reverse transcriptase (RT) inhibitors. Because both treatments are less than ideal, we conducted to identify novel ...

Synonyms

9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine

BIS POM PMEA

ADEFOVIR PIVOXIL

Adefovir Dipivoxil

9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine

Hepsera

ADEFOVIR DIPVOXIL

Preveon

MFCD00869897

EINECS 200-001-8

ADEFOVIR DIPIVOLIX

Adefovir Dipivoxyl

Adefovir Dipivoxi

Adefovir Dipivoxl

Adefovir Impurity 3

Recommended......