CAS 7080-50-4|Chloramine-T trihydrate
Introduction：Basic information about CAS 7080-50-4|Chloramine-T trihydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chloramine-T trihydrate | ||
|---|---|---|---|
| CAS Number | 7080-50-4 | Molecular Weight | 281.690 |
| Density | / | Boiling Point | / |
| Molecular Formula | C7H13ClNNaO5S | Melting Point | 167-170 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 92 °C |
| Symbol | GHS05, GHS07, GHS08 | Signal Word | Danger |
Names
| Name | Chloramine-T trihydrate |
|---|---|
| Synonym | More Synonyms |
Chloramine-T trihydrate BiologicalActivity
| Description | Tosylchloramide sodium trihydrate (Chloramine T sodium trihydrate) is a disinfectant agent widely used in laboratories, kitchens and hospitals. It is also used as a biocide in air fresheners and deodorants. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
| In Vitro | Gram-positive growth is reduced by 95% to 100% after tosylchloramide treatment, regardless of dose, with or without serum. E coli (gram-negative; with/without serum) is reduced 94% to 100% at antiseptic concentrations of 300 and 400 ppm. At 200 ppm, E coli growth is fully inhibited without serum present and by 50% with serum. At 100 and 200 ppm, cell viability remains greater than 90% under all experimental conditions. A 300-ppm, 3-minute exposure to tosylchloramide results in cell viability of up to 70%, with longer exposures producing lower viabilities. Serum does not affect cell viability in any condition[1]. |
| In Vivo | A dose-dependently significant DNA damage in the rat tissues and inflammation is histopathologically noted around the terminal airways of the lung in both male and female rats[2]. The 24-h exposure to 50 mg/L of chloramine-T is toxic for crayfish and leads to substantial loss of energy that became apparent during subsequently conducted physical stress[3]. Tosylchloramide may potentiate the toxicity of many xenobiotics via metabolic activation and/or accumulation of reactive metabolites. The activities of CYP2E1, CYP1A1/2 CYP2B1/2, CYP3A4 and CYP4A1/2 enzymes significantly increase after treatment with 2.50, 5 and 10 mg/kg bw/day tosylchloramide, in a dose-dependent manner. This effect is not observed after tosylchloramide treatment at dose of 1.25 mg/kg bw/day[4]. |
| Animal Admin | Rats: Male and female groups of rats are exposed to tosylchloramide at concentrations of 0.2, 0.9 and 4 mg/m3 for 6 hr/day, 5 days/week during 4 weeks. All rats are sacrificed after treatment for 4 weeks[2]. |
| References | [1]. Kloth LC, et al. Bactericidal and cytotoxic effects of chloramine-T on wound pathogens and human fibroblasts in vitro. Adv Skin Wound Care. 2007 Jun;20(6):331-45. [2]. Shim I, et al. Inhalation exposure to chloramine T induces DNA damage and inflammation in lung of Sprague-Dawley rats. J Toxicol Sci. 2013;38(6):937-46. [3]. Kuklina I, et al. Investigation of chloramine-T impact on crayfish Astacus leptodactylus (Esch., 1823) cardiac activity. Environ Sci Pollut Res Int. 2014 Sep;21(17):10262-9. [4]. Martínez MA, et al. Induction of cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation by chloramine-T in male rat liver. Food Chem Toxicol. 2017 Aug;106(Pt A):86-91. |
Chemical & Physical Properties
| Melting Point | 167-170 °C(lit.) |
|---|---|
| Molecular Formula | C7H13ClNNaO5S |
| Molecular Weight | 281.690 |
| Flash Point | 92 °C |
| Exact Mass | 281.010071 |
| PSA | 70.21000 |
| LogP | 3.09910 |
| InChIKey | NZYOAGBNMCVQIV-UHFFFAOYSA-N |
| SMILES | Cc1ccc(S(=O)(=O)[N-]Cl)cc1.O.O.O.[Na+] |
| Storage condition | 0-6°C |
Safety Information
| Symbol | GHS05, GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H314-H334 |
| Supplemental HS | Contact with acids liberates toxic gas. |
| Precautionary Statements | P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | C:Corrosive |
| Risk Phrases | R22;R31;R34;R42 |
| Safety Phrases | S22-S26-S36/37/39-S45 |
| RIDADR | UN 3263 8/PG 3 |
| WGK Germany | 2 |
| RTECS | XT5616800 |
| Packaging Group | III |
| Hazard Class | 8 |
Articles27
More Articles| Catalytic diastereoselective sulfimidation of diaryl sulfides and application of chiral sulfimides to asymmetric allylic alkylation. Chirality 12(5-6) , 299-312, (2000) The copper-catalyzed diastereoselective imidation of diaryl sulfides bearing a chiral oxazolinyl moiety at the ortho-position with [N-(p-toluenesulfonyl) imino]phenyliodinane (TsN=IPh) or Chloramine-T... | |
| The estimation of microgram amounts of methionine by reaction with chloramine-T. Anal. Biochem. 93 , 419, (1979) | |
| THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem. J. 89 , 114, (1963) |
Synonyms
| N-chloro-toluene-4-sulfonamide,sodium salt |
| Chloramine-T trihydrate |
| MFCD00149066 |
| TOSYLCHLORAMIDE SODIUM TRIHYDRATE |
| ChloraMine T&chloroamine T trihydrate |
| sodium chloro[(4-methylphenyl)sulfonyl]azanide trihydrate |
| CHLORAMINE T GR |
| CHLORAMINE T 3-HYDRATE |
| CHLORAMINE T TRIHYDRATE |
| N-Chloro-p-toluenesulfonamide sodium salt trihydrate |
| chloramine T hydratee |
| CHLOROMINE-T SOLUTION |
| Sodium chloro[(4-methylphenyl)sulfonyl]azanide hydrate (1:1:3) |
| Chloroamine t trihydrate |
| Benzenesulfonamide, N-chloro-4-methyl-, sodium salt, hydrate (1:1:3) |
| CHLOROAMINUM |
| Chloramine-T,Sodium salt |
| EINECS 204-854-7 |
