CAS 3569-99-1|N-(Hydroxymethyl)nicotinamide

Introduction：Basic information about CAS 3569-99-1|N-(Hydroxymethyl)nicotinamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. N-(Hydroxymethyl)nicotinamide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles2
8. Synonyms

Common Name	N-(Hydroxymethyl)nicotinamide
CAS Number	3569-99-1	Molecular Weight	152.151
Density	1.3±0.1 g/cm3	Boiling Point	427.7±25.0 °C at 760 mmHg
Molecular Formula	C₇H₈N₂O₂	Melting Point	152-154 °C(lit.)
MSDS	USA	Flash Point	212.5±23.2 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	N-(hydroxymethyl)pyridine-3-carboxamide
Synonym	More Synonyms

N-(Hydroxymethyl)nicotinamide BiologicalActivity

Description	N-(Hydroxymethyl)nicotinamide is an antimicrobic agent[1].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial
References	[1]. Zhang HK, et, al. [Study on the synthesis of N-hydroxymethyl-nicotinamide]. Yao Xue Xue Bao. 1992; 27(8): 629-31.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	427.7±25.0 °C at 760 mmHg
Melting Point	152-154 °C(lit.)
Molecular Formula	C₇H₈N₂O₂
Molecular Weight	152.151
Flash Point	212.5±23.2 °C
Exact Mass	152.058578
PSA	62.22000
LogP	-0.80
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.569
InChIKey	JRFKIOFLCXKVOT-UHFFFAOYSA-N
SMILES	O=C(NCO)c1cccnc1
Storage condition	-20?C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QS4476500

CHEMICAL NAME :: Nicotinamide, N-(hydroxymethyl)-

CAS REGISTRY NUMBER :: 3569-99-1

BEILSTEIN REFERENCE NO. :: 0128633

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H8-N2-O2

MOLECULAR WEIGHT :: 152.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 305,427,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 17,73,1960

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	QS4476500
HS Code	2933399090

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles2

[Study on the synthesis of N-hydroxymethyl-nicotinamide].

Yao Xue Xue Bao 27(8) , 629-31, (1992)

N-Hydroxymethyl-nicotinamide, an antimicrobic agent was prepared in good yield by treating nicotinamide with excess of formaldehyde in the presence of potassium carbonate. The condensation reaction wa...

Thin-layer chromatography-densitometric measurements for determination of N-(hydroxymethyl)nicotinamide in tablets and stability evaluation in solutions.

J. AOAC Int. 91(5) , 1186-90, (2008)

A thin-layer chromatography (TLC)-densitometric method was developed to determine N-(hydroxymethyl)nicotinamide in tablets and basic solutions along with nicotinic acid. Analysis was performed on sili...

Synonyms

Pyridine-3-carboxylic Acid N-Methylolamide

3-Pyridinecarboxamide, N-(hydroxymethyl)-

Nicodine

Bilizorin

Cholamid

EINECS 222-668-4

Bilamid

3-Pyridinecarboxylic acid N-hydroxymethylamide

Nicoform

Cholamide

MFCD00010437

Nikomethamide

N-(hydroxymethyl)pyridine-3-carboxamide

Bilocid

N-(Hydroxymethyl)nicotinamide

Nicodin

hydroxymethylnicotinamide

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