CAS 353-09-3|RGX-202
| Common Name | RGX-202 | ||
|---|---|---|---|
| CAS Number | 353-09-3 | Molecular Weight | 131.133 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 299.1±42.0 °C at 760 mmHg |
| Molecular Formula | C4H9N3O2 | Melting Point | 222 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 134.7±27.9 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 3-guanidinopropanoic acid |
|---|---|
| Synonym | More Synonyms |
RGX-202 BiologicalActivity
| Description | RGX-202 is an oral small-molecule SLC6A8 transporter inhibitor. RGX-202 robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. RGX-202 can be used for the research of cancer[1]. |
|---|---|
| Related Catalog | Research Areas >>Cancer |
| Target | Human Endogenous Metabolite |
| In Vitro | RGX-202 (10 μM; 96 hours) reduces cell growth, and reveals a nearly complete depletion of phosphocreatine (>99%), greater than 79% reduction in cellular creatine and a substantial (46%) reduction in intracellular ATP levels relative to control cells in hypoxia[1]. |
| In Vivo | RGX-202 (800 mg/kg; p.o. for 35 days) reduces UN-KPC-961 pancreatic tumoral creatine levels in B6129SF1/J mice[1]. RGX-202 (approximately 650 mg/kg; i.p. daily for 14 days) treatment reduces Lvm3b cells liver metastatic colonization by eightfold in NOD-SCID mice[1]. Animal Model: UN-KPC-961 pancreatic tumor-bearing B6129SF1/J mice[1] Dosage: 800 mg/kg Administration: p.o. for 35 days Result: Suppressed tumoral d3-creatine import by 50% at 800 mg/kg. Animal Model: 6- to 9-week-old C57BL/6J male wild-type mice[1] Dosage: 100, 250, 500 mg/KG in sterile 0.9% NaCl Administration: p.o. for 35 days Result: Inhibited tissue uptake of d3-creatine in a dose-dependent manner by up to 75% at 500 mg/kg. |
| References | [1]. Kurth I, et al. Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels. Sci Adv. 2021 Oct 8;7(41):eabi7511. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 299.1±42.0 °C at 760 mmHg |
| Melting Point | 222 °C (dec.)(lit.) |
| Molecular Formula | C4H9N3O2 |
| Molecular Weight | 131.133 |
| Flash Point | 134.7±27.9 °C |
| Exact Mass | 131.069473 |
| PSA | 99.20000 |
| LogP | -1.68 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.575 |
| InChIKey | KMXXSJLYVJEBHI-UHFFFAOYSA-N |
| SMILES | NC(N)=NCCC(=O)O |
| Storage condition | −20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AY3157500 |
| HS Code | 2925290090 |
Customs
| HS Code | 2925290090 |
|---|---|
| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
Articles36
More Articles| Novel parent structures for inhibitors of the murine GABA transporters mGAT3 and mGAT4. Eur. J. Pharmacol. 519(1-2) , 43-7, (2005) Searching for potent and subtype selective parent structures of the murine gamma-aminobutyric acid (GABA) transporter subtypes mGAT3 and mGAT4 a series of amino acids was characterised in a uniform [3... | |
| Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1). Bioorg. Med. Chem. 19 , 6409-18, (2011) The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati... | |
| Accumulation of methylguanidine and changes in guanidino compound levels in plasma, urine, and kidneys of furosemide-treated rats. Metab. Clin. Exp. 57(6) , 802-10, (2008) Antidiuresis and renal diseases alter the levels of guanidino compounds (GCs) in various tissues. Therefore, we hypothesized that diuresis could also disturb GC metabolism, storage, and elimination. I... |
Synonyms
| EINECS 206-530-0 |
| β-Alanine, N-(aminoiminomethyl)- |
| 3-(diaminomethylideneamino)propanoic acid |
| n-carbamimidoyl-|A-alanine |
| beta-Guanidinopropionic acid |
| 3-Guanidinopropanoate |
| 3-carbamimidamidopropanoic acid |
| N-Carbamimidoyl-β-alanine |
| N-(Aminomethyl)-β-alanine |
| MFCD00045939 |
| Guanidinopropionic acid |
| 3-Guanidinopropionic Acid |
| β-Guanidinopropionic acid |
| b-Guanidinopropionate |
| 3-Guanidinopropanoic acid |
| 3-guanidinepropionic acid |
