CAS 122852-69-1|Alosetron hydrochloride
| Common Name | Alosetron hydrochloride | ||
|---|---|---|---|
| CAS Number | 122852-69-1 | Molecular Weight | 330.812 |
| Density | 1.34g/cm3 | Boiling Point | 648.1ºC at 760 mmHg |
| Molecular Formula | C17H19ClN4O | Melting Point | 288-291ºC |
| MSDS | ChineseUSA | Flash Point | 345.8ºC |
| Symbol | GHS06, GHS09 | Signal Word | Danger |
Names
| Name | alosetron hydrochloride |
|---|---|
| Synonym | More Synonyms |
Alosetron hydrochloride BiologicalActivity
| Description | Alosetron Hcl is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.IC50 Value: Target: 5-HT ReceptorAlosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract. While being a 5-HT3 antagonist like ondansetron, it is not classified or approved as an antiemetic. Since stimulation of 5-HT3 receptors is positively correlated with gastrointestinal motility, alosetron's 5-HT3 antagonism slows the movement of fecal matter through the large intestine, increasing the extent to which water is absorbed, and decreasing the moisture and volume of the remaining waste products. From Wikipedia. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorResearch Areas >>Neurological Disease |
| References | [1]. Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome By Spiller, Robin C. From Current Opinion in Pharmacology (2011), 11(1), 68-74. [2]. Lucak SL. Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome. Therap Adv Gastroenterol. 2010 May;3(3):165-72. [3]. Lewis JH. Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective. Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):13-29. [4]. Turgeon DK, Tayeh N, Fontana RJ. Acute hepatitis associated with alosetron (Lotronex). J Clin Gastroenterol. 2005 Aug;39(7):641-2. [5]. Miller DP, Alfredson T, Cook SF, Sands BE, Walker AM. Incidence of colonic ischemia, hospitalized complications of constipation, and bowel surgery in relation to use of alosetron hydrochloride. Am J Gastroenterol. 2003 May;98(5):1117-22. |
Chemical & Physical Properties
| Density | 1.34g/cm3 |
|---|---|
| Boiling Point | 648.1ºC at 760 mmHg |
| Melting Point | 288-291ºC |
| Molecular Formula | C17H19ClN4O |
| Molecular Weight | 330.812 |
| Flash Point | 345.8ºC |
| Exact Mass | 330.124725 |
| PSA | 53.92000 |
| LogP | 3.14820 |
| Vapour Pressure | 1.1E-16mmHg at 25°C |
| InChIKey | FNYQZOVOVDSGJH-UHFFFAOYSA-N |
| SMILES | Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O.Cl |
| Storage condition | Refrigerator |
Safety Information
| Symbol | GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H319-H411 |
| Precautionary Statements | P273-P301 + P310-P305 + P351 + P338 |
| Hazard Codes | T,Xi |
| Risk Phrases | 25-36-52/53 |
| Safety Phrases | 26-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles25
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Synonyms
| Alosetron hydrochloride |
| 5-méthyl-2-[(4-méthyl-1H-imidazol-5-yl)méthyl]-2,3,4,5-tétrahydro-1H-pyrido[4,3-b]indol-1-one chlorhydrate |
| gr 68755c |
| 1H-pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride |
| 1H-Pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-, hydrochloride (1:1) |
| 1H-pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-, hydrochloride (1:1) |
| LOTRONEX |
| MFCD03453647 |
| Alosetron HCl |
| GR-68755C |
| 5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one hydrochloride |
| 5-Methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one hydrochloride (1:1) |
| 5-Methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-onhydrochlorid |
| Alosetron (Hydrochloride) |
