CAS 7554-65-6|Fomepizole
Introduction：Basic information about CAS 7554-65-6|Fomepizole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fomepizole | ||
|---|---|---|---|
| CAS Number | 7554-65-6 | Molecular Weight | 82.104 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 243.6±0.0 °C at 760 mmHg |
| Molecular Formula | C4H6N2 | Melting Point | 13°C |
| MSDS | ChineseUSA | Flash Point | 96.1±0.0 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | fomepizole |
|---|---|
| Synonym | More Synonyms |
Fomepizole BiologicalActivity
| Description | Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
| References | [1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170. [2]. Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009 Apr;53(4):439-450.e10. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 243.6±0.0 °C at 760 mmHg |
| Melting Point | 13°C |
| Molecular Formula | C4H6N2 |
| Molecular Weight | 82.104 |
| Flash Point | 96.1±0.0 °C |
| Exact Mass | 82.053101 |
| PSA | 28.68000 |
| LogP | 0.78 |
| Vapour Pressure | 0.1±0.4 mmHg at 25°C |
| Index of Refraction | 1.523 |
| InChIKey | RIKMMFOAQPJVMX-UHFFFAOYSA-N |
| SMILES | Cc1cn[nH]c1 |
| Storage condition | 2-8°C |
| Water Solubility | soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 534 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,1198,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 310 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,1198,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 640 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,1198,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 310 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,1198,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg/4D-I
- TOXIC EFFECTS :
- Behavioral - fluid intake Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 39,513,1976
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S36-S24/25 |
| RIDADR | 2810 |
| WGK Germany | 3 |
| RTECS | UQ7350000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2933199090 |
Customs
| HS Code | 2933199090 |
|---|---|
| Summary | 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 4-Methylpyrazol |
| 4-MP |
| EINECS 231-445-0 |
| Fomepizolefreebase |
| 4-methyl-pyrazol |
| Antizol-Vet |
| 1H-4-methylpyrazole |
| 4-Methyl-1H-pyrazole |
| Antizol |
| 4-METHYLPYRRAZOLE |
| 3-methyl-1H-pyrazole |
| 1H-Pyrazole, 4-methyl- |
| 4-Methylpyrazole |
| T5MNJ D1 |
| 4-methyl-1H-pyrazol |
| Fomepizole |
| fomepizol |
| MFCD00005245 |
