Introduction：Basic information about CAS 90105-47-8|H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt |
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| CAS Number | 90105-47-8 | Molecular Weight | 388.89000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C17H29ClN4O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | H-Ala-Ala-Pro-Val-chloromethylketone |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>ElastaseResearch Areas >>Inflammation/Immunology |
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| In Vivo | Methoxysuccinyl-Ala-Ala-Pro-Val chloromethylketone (oropharyngeal aspiration; 85 μM, 40 μL; days 1, 4, and 7) blocks NE-induced cupped cell chemotaxis and significantly reduces Muc5ac gene and protein expression in male Balb/c mice[1]. |
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Chemical & Physical Properties
| Molecular Formula | C17H29ClN4O4 |
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| Molecular Weight | 388.89000 |
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| Exact Mass | 388.18800 |
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| PSA | 121.60000 |
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| LogP | 1.19800 |
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| InChIKey | LRFJEIMSBAPTLB-MNXVOIDGSA-N |
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| SMILES | CC(N)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(=O)CCl)C(C)C |
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Synonyms
| h-ala-ala-pro-val-cmk |
| ala-ala-pro-val-chloromethylketone |
| ala-ala-pro-val-cmk |
