CAS 141663-86-7|Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2

Introduction：Basic information about CAS 141663-86-7|Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
CAS Number	141663-86-7	Molecular Weight	900.07400
Density	/	Boiling Point	/
Molecular Formula	C₄₇H₆₅N₉O₉	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
Synonym	More Synonyms

Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 BiologicalActivity

Description	GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor
Target	NK2
In Vitro	GR 87389 是一种非肽和肽速激肽拮抗剂，对海马、膀胱和十二指肠的 Ki 值分别为 4.0、5.2 和 14 nM[1]。 GR 87389 (30-300 nM) 拮抗 GA 64349 诱导的人类逼尿肌、前列腺和前列腺尿道平滑肌条收缩[2]。
References	[1]. Saffroy M, et, al. Presence of NK2 binding sites in the rat brain. J Neurochem. 2001 Dec;79(5):985-96. [2]. Palea S, et, al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996 May;277(2):700-5.

Chemical & Physical Properties

Molecular Formula	C₄₇H₆₅N₉O₉
Molecular Weight	900.07400
Exact Mass	899.49100
PSA	254.23000
LogP	5.01350
InChIKey	TULKQVVKMIIQFE-DWZVVYGRSA-N
SMILES	CCCCC(NC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(Cc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(C)NC(=O)C(C)NC(=O)OC(C)(C)C)C(N)=O

Synonyms

boc-ala-ala-d-trp-phe-d-pro-pro-nle-nh2

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