CAS 113873-67-9|Calcineurin Substrate trifluoroacetate salt
| Common Name | Calcineurin Substrate trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 113873-67-9 | Molecular Weight | 2112.35000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C92H150N28O29 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Calcineurin substrate |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. It can be used in the calcineurin activity assay. |
|---|---|
| Related Catalog | Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Neurological DiseasePeptides |
| In Vitro | Calcineurin (PP2B), a serine/threonine phosphatase controlled by cellular calcium, has been implicated in a wide variety of biological responses including lymphocyte activation, neuronal and muscle development, neurite outgrowth, and morphogenesis of vertebrate heart valves[1]. |
| References | [1]. Crabtree GR, et al. Calcium, calcineurin, and the control of transcription. J Biol Chem. 2001 Jan 26;276(4):2313-6. |
Chemical & Physical Properties
| Molecular Formula | C92H150N28O29 |
|---|---|
| Molecular Weight | 2112.35000 |
| Exact Mass | 2111.11000 |
| PSA | 924.67000 |
| LogP | 1.58550 |
| InChIKey | CNNRZOUCQVLOST-RBHZDPOXSA-N |
| SMILES | CCC(C)C(NC(=O)C1CCCN1C(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(N)CC(=O)O)C(C)C)C(=O)N1CCCC1C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(CO)C(=O)NC(C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)O)C(C)C)C(C)C |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles3
More Articles| Endoplasmic reticulum vacuolation and unfolded protein response leading to paraptosis like cell death in cyclosporine A treated cancer cervix cells is mediated by cyclophilin B inhibition. Biochim. Biophys. Acta 1843(11) , 2497-512, (2014) Cyclosporine A (CsA), a widely used immunosuppressant shows cytotoxic effects by either inducing apoptosis or redirecting the cell towards non-apoptotic cell death. However, there still remains a lacu... | |
| Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB. Retrovirology 12 , 23, (2015) The exact molecular mechanisms regarding HTLV-1 Tax-mediated viral gene expression and CD4 T-cell transformation have yet to be fully delineated. Herein, utilizing virus-infected primary CD4+ T cells ... | |
| Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate. Anal. Biochem. 216 , 147, (1994) Currently, protein phosphatase 2B (calcineurin) activity is assayed based on release of [32P]phosphate from a 19-amino acid peptide (partial sequence of the regulatory subunit of cAMP-dependent protei... |
Synonyms
| MFCD00236901 |
| DLDVPIPGRFDRRVSVAAE |
