Introduction：Basic information about CAS 118072-93-8|Zoledronic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Zoledronic acid |
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| CAS Number | 118072-93-8 | Molecular Weight | 272.090 |
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| Density | 2.1±0.1 g/cm3 | Boiling Point | 764.0±70.0 °C at 760 mmHg |
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| Molecular Formula | C5H10N2O7P2 | Melting Point | 193-2040ºC |
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| MSDS | / | Flash Point | 415.8±35.7 °C |
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Names
| Name | zoledronic acid |
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| Synonym | More Synonyms |
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Zoledronic acid BiologicalActivity
| Description | Zoledronic Acid is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity. |
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| Related Catalog | Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Cancer |
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| In Vitro | Zoledronic Acid induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2]. |
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| References | [1]. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr 1;3:6. [2]. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation. Clin Exp Pharmacol Physiol. 2018 Jun 8. |
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Chemical & Physical Properties
| Density | 2.1±0.1 g/cm3 |
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| Boiling Point | 764.0±70.0 °C at 760 mmHg |
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| Melting Point | 193-2040ºC |
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| Molecular Formula | C5H10N2O7P2 |
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| Molecular Weight | 272.090 |
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| Flash Point | 415.8±35.7 °C |
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| Exact Mass | 271.996338 |
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| PSA | 172.73000 |
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| LogP | -2.28 |
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| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
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| Index of Refraction | 1.719 |
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| InChIKey | XRASPMIURGNCCH-UHFFFAOYSA-N |
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| SMILES | O=P(O)(O)C(O)(Cn1ccnc1)P(=O)(O)O |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R21/22 |
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| Safety Phrases | 24/25-36/37/39 |
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| HS Code | 2933290090 |
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Customs
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| zoledronate |
| Zoledronic acid monohydrate |
| P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate |
| acide [1-hydroxy-2-(1H-imidazol-1-yl)éthane-1,1-diyl]bis(phosphonique) |
| hydrogen [1-hydroxy-2-(1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate |
| [1-Hydroxy-2-(1H-imidazol-1-yl)-1,1-ethanediyl]bis(phosphonic acid) |
| Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis- |
| [1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) |
| Zometa,Zomera,Aclasta and Reclast |
| MFCD00867791 |
| [1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid |
| [1-Hydroxy-2-(1H-imidazol-1-yl)ethan-1,1-diyl]bis(phosphonsäure) |
| Zoledronic acid |
| Phosphonic acid (P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis |
| [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid |
| (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid |
| 2-(Imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic Acid |
| [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate |
