Introduction：Basic information about CAS 30675-13-9|TCID, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | TCID |
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| CAS Number | 30675-13-9 | Molecular Weight | 283.923 |
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| Density | 1.8±0.1 g/cm3 | Boiling Point | 448.1±45.0 °C at 760 mmHg |
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| Molecular Formula | C9H2Cl4O2 | Melting Point | 218-220ºC |
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| MSDS | ChineseUSA | Flash Point | 188.8±29.3 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 4,5,6,7-tetrachloroindene-1,3-dione |
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| Synonym | More Synonyms |
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TCID BiologicalActivity
| Description | TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM[1]. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Cell Cycle/DNA Damage >>Deubiquitinase |
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| Target | IC50: 0.6 μM (UCH-L3) and 75 μM (UCH-L1)[1] |
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| In Vitro | TCID (4,5,6,7-Tetrachloroindan-1,3-dione; compound 11) inhibits UCH-L1 with an IC50 of 75 μM[1]. TCID (10 μM; 1, 2 hours) diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2]. |
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| References | [1]. Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cellline. Chem Biol. 2003 Sep;10(9):837-46. [2]. de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013;8(3):e58863. |
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Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
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| Boiling Point | 448.1±45.0 °C at 760 mmHg |
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| Melting Point | 218-220ºC |
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| Molecular Formula | C9H2Cl4O2 |
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| Molecular Weight | 283.923 |
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| Flash Point | 188.8±29.3 °C |
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| Exact Mass | 281.880890 |
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| PSA | 34.14000 |
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| LogP | 3.94 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.652 |
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| InChIKey | IDLAOWFFKWRNHB-UHFFFAOYSA-N |
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| SMILES | O=C1CC(=O)c2c(Cl)c(Cl)c(Cl)c(Cl)c21 |
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| Storage condition | -20℃ |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302 |
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| Precautionary Statements | P301 + P312 + P330 |
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| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2914700090 |
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Customs
| HS Code | 2914700090 |
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| Summary | HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 1H-Indene-1,3(2H)-dione, 4,5,6,7-tetrachloro- |
| 4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione |
| Ubiquitin C-Terminal Hydrolase L3 Inhibitor |
| Ubiquitin Thiolesterase L3 Inhibitor |
| 4,5,6,7-Tetrachloroindan-1,3-dione |
| 4,5,6,7-Tetrachlorindan-1,3-dion |
| 4,5,6,7-Tetrachlorphenyl-1,3-indandion |
| 4,5,6,7-tetrachloroindane-1,3-dione |
| UCH-L3 Inhibitor |
| TCID |
| Ubiquitin C-Terminal Esterase L3 Inhibitor |
