CAS 6803-19-6|Glycine, L-g-glutamyl-S-[(4-nitrophenyl)methyl]-L-cysteinyl-
Introduction：Basic information about CAS 6803-19-6|Glycine, L-g-glutamyl-S-[(4-nitrophenyl)methyl]-L-cysteinyl-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Glycine, L-g-glutamyl-S-[(4-nitrophenyl)methyl]-L-cysteinyl- | ||
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| CAS Number | 6803-19-6 | Molecular Weight | 442.44400 |
| Density | 1.464g/cm3 | Boiling Point | 877.1ºC at 760 mmHg |
| Molecular Formula | C17H22N4O8S | Melting Point | / |
| MSDS | / | Flash Point | 484.2ºC |
Names
| Name | S-(4-nitrobenzyl)glutathione |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | S-(p-Nitrobenzyl)glutathione is a competitive glutathionase inhibitor. S-(p-Nitrobenzyl)glutathione is converted to the corresponding cysteine derivatives by rat kidney microsomes. S-(p-Nitrobenzyl)glutathione can be used for the research of metabolic breakdown of glutathione by the glutathionase system[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
Chemical & Physical Properties
| Density | 1.464g/cm3 |
|---|---|
| Boiling Point | 877.1ºC at 760 mmHg |
| Molecular Formula | C17H22N4O8S |
| Molecular Weight | 442.44400 |
| Flash Point | 484.2ºC |
| Exact Mass | 442.11600 |
| PSA | 229.94000 |
| LogP | 1.71100 |
| Index of Refraction | 1.618 |
| InChIKey | OAWORKDPTSAMBZ-STQMWFEESA-N |
| SMILES | NC(CCC(=O)NC(CSCc1ccc([N+](=O)[O-])cc1)C(=O)NCC(=O)O)C(=O)O |
Safety Information
Articles6
More Articles| Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors. J. Mol. Biol. 237(3) , 298-314, (1994) The three-dimensional crystal structure of pi class glutathione S-transferase YfYf from mouse liver complexed with the inhibitor S-(p-nitrobenzyl)glutathione has been determined at 1.8 A resolution by... | |
| The three-dimensional structure of Cys-47-modified mouse liver glutathione S-transferase P1-1. Carboxymethylation dramatically decreases the affinity for glutathione and is associated with a loss of electron density in the alphaB-310B region. J. Biol. Chem. 273(5) , 2844-50, (1998) The three-dimensional structure of mouse liver glutathione S-transferase P1-1 carboxymethylated at Cys-47 and its complex with S-(p-nitrobenzyl)glutathione have been determined by x-ray diffraction an... | |
| Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for 'ping pong' kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione. FEBS J. 278(2) , 273-81, (2011) Mouse liver glutathione transferase P1-1 has three cysteine residues at positions 14, 47 and 169. We have constructed the single, double and triple cysteine to alanine mutants to define the behaviour ... |
Synonyms
| s-(p-nitrobenzyl)glutathione |
