CAS 5987-82-6|benoxinate hydrochloride
Introduction：Basic information about CAS 5987-82-6|benoxinate hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | benoxinate hydrochloride | ||
|---|---|---|---|
| CAS Number | 5987-82-6 | Molecular Weight | 344.877 |
| Density | / | Boiling Point | 446.9ºC at 760 mmHg |
| Molecular Formula | C17H29ClN2O3 | Melting Point | 158 - 162ºC |
| MSDS | / | Flash Point | 224.1ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | oxybuprocaine hydrochloride |
|---|---|
| Synonym | More Synonyms |
benoxinate hydrochloride BiologicalActivity
| Description | Oxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine hydrochloride is used especially in ophthalmology and otolaryngology[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Neurological Disease |
| In Vivo | Oxybuprocaine hydrochloride (Benoxinate hydrochloride; 27.6, 51.7, 103.5, 413.9 μg; s.c.) provides a dose-dependent block to pinpricks in rats[1]. Oxybuprocaine hydrochloride (27.6 μg) produces 100% of sensory/nociceptive block[1]. Animal Model: Male Sprague-Dawley rats (203-253 g)[1] Dosage: 27.6, 51.7, 103.5, 413.9 μg Administration: SC Result: Provided a dose-dependent block to pinpricks. |
| References | [1]. Chen YW, et al. The Addition of Epinephrine to Proxymetacaine or Oxybuprocaine Solution Increases the Depth and Duration of Cutaneous Analgesia in Rats. Reg Anesth Pain Med. 2016 Sep-Oct;41(5):601-6. [2]. Chen YW, et al. Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats. Anesth Analg. 2018 May;126(5):1721-1728. [3]. Page M, et al. Safety, efficacy, and patient acceptability of lidocaine hydrochloride ophthalmic gel as a topicalocular anesthetic for use in ophthalmic procedures. Clin Ophthalmol. 2009;3:601-9. Epub 2009 Nov 2. |
Chemical & Physical Properties
| Boiling Point | 446.9ºC at 760 mmHg |
|---|---|
| Melting Point | 158 - 162ºC |
| Molecular Formula | C17H29ClN2O3 |
| Molecular Weight | 344.877 |
| Flash Point | 224.1ºC |
| Exact Mass | 344.186676 |
| PSA | 64.79000 |
| LogP | 4.32950 |
| InChIKey | PRGUDWLMFLCODA-UHFFFAOYSA-N |
| SMILES | CCCCOc1cc(C(=O)OCCN(CC)CC)ccc1N.Cl |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 42500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >6800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1957,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 4200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S26-S36 |
| RIDADR | UN 1544PSN2 6.1 / PGIII |
| RTECS | DG15029 |
| HS Code | 29225000 |
Customs
| HS Code | 29225000 |
|---|
Articles17
More Articles| Postoperative changes in amniotic membrane as a carrier for allogeneic cultured limbal epithelial transplantation. Am. J. Ophthalmol. 158(6) , 1192-1198.e1, (2014) To investigate the morphologic changes and outcomes of the amniotic membrane as a carrier for allogeneic cultivated limbal epithelial transplantation.Prospective, noncomparative, interventional study.... | |
| The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs. PLoS ONE 9(5) , e96952, (2014) To investigate whether the Sonic hedgehog (Shh) signaling induces myopic development by increasing the expression of matrix metalloproteinase (MMP)-2 in guinea pigs.A translucent diffuser was glued on... | |
| Corneal thickness differences between sexes after oxybuprocaine eye drops. Optom. Vis. Sci. 92(1) , 89-94, (2015) We aimed to analyze the corneal thickness (CT) values of female and male subjects before and after instillation of oxybuprocaine 0.4% anesthetic eye drops.The CT of 30 female subjects and 28 male subj... |
Synonyms
| Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester, hydrochloride (1:1) |
| 2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate hydrochloride (1:1) |
| Oxybuprocaine HCL |
| 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate,hydrochloride |
| Benoxinate hydrochloride |
| 2-(Diethylamino)ethyl-4-amino-3-butoxybenzolcarboxylathydrochlorid |
| MFCD00012512 |
| EINECS 227-808-8 |
| oxybuprocaine hydrochloride |
