CAS 84-60-6|2,6-DIHYDROXY-ANTHRAQUINONE
| Common Name | 2,6-DIHYDROXY-ANTHRAQUINONE | ||
|---|---|---|---|
| CAS Number | 84-60-6 | Molecular Weight | 240.211 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 442.1±35.0 °C at 760 mmHg |
| Molecular Formula | C14H8O4 | Melting Point | >320 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 235.3±22.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | anthraflavic acid |
|---|---|
| Synonym | More Synonyms |
2,6-DIHYDROXY-ANTHRAQUINONE BiologicalActivity
| Description | Anthraflavic acid, a flavonoid, is a potent IQ mutagenicity inhibitor by virtue of its ability to inhibit both its microsomal and cytosolic activation pathways. Anthraflavic acid is a potent and specific cytochrome P-448 inhibitor activity an enzyme system closely associated with the activation of many chemical carcinogens[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
| References | [1]. Ayrton AD, et al. Anthraflavic acid inhibits the mutagenicity of the food mutagen IQ: mechanism of action. Mutat Res. 1988 Mar-Apr;207(3-4):121-5. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 442.1±35.0 °C at 760 mmHg |
| Melting Point | >320 °C(lit.) |
| Molecular Formula | C14H8O4 |
| Molecular Weight | 240.211 |
| Flash Point | 235.3±22.4 °C |
| Exact Mass | 240.042252 |
| PSA | 74.60000 |
| LogP | 3.36 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.733 |
| InChIKey | APAJFZPFBHMFQR-UHFFFAOYSA-N |
| SMILES | O=C1c2ccc(O)cc2C(=O)c2ccc(O)cc21 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | CB6675000 |
| HS Code | 2914690090 |
Customs
| HS Code | 2914690090 |
|---|---|
| Summary | 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
Articles14
More Articles| Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg. Med. Chem. Lett. 11(14) , 1839-42, (2001) The methanolic extract from the roots of Polygonum (P.) cuspidatum was found to enhance cell proliferation at 30 or 100 microg/mL in MCF-7, an estrogen-sensitive cell line. By bioassay-guided separati... | |
| Mutagenicity of anthraquinone and hydroxylated anthraquinones in the Ames/Salmonella microsome system. Appl. Environ. Microbiol. 43(6) , 1354-9, (1982) The mutagenicity of anthracene, anthraquinone, and four structurally similar compounds of each was evaluated in the Ames/Salmonella microsome assay. Anthraquinone was shown to be mutagenic for strains... | |
| A compact optical instrument with artificial neural network for pH determination. Sensors (Basel.) 12 , 6746-63, (2012) The aim of this work was the determination of pH with a sensor array-based optical portable instrument. This sensor array consists of eleven membranes with selective colour changes at different pH int... |
Synonyms
| 2,6-DIHYDROXY-ANTHRAQUINONE |
| 2,6-Dihydroxy-9,10-anthraquinone |
| EINECS 201-544-3 |
| 2,6-DIHYDROXYANTHRAQUINONE |
| MFCD00001228 |
| 9,10-Anthracenedione, 2,6-dihydroxy- |
| 2,6-Dihydroxyanthracene-9,10-dione |
