Introduction：Basic information about CAS 57-71-6|Diacetyl monoxime, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime induces sarcoplasmic reticulum Ca2+ release[1][2].
Related Catalog
Research Areas >>Metabolic Disease
References
[1]. Kohsuke Hashimoto, et al. The myosin ATPase inhibitor, 2,3-butanedione 2-monoxime, prevents protein secretion by the basidiomycete Coprinopsis cinerea. Biotechnol Lett. 2011 Apr;33(4):769-75.
[2]. R M Phillips, et al. 2,3-Butanedione 2-monoxime (BDM) induces calcium release from canine cardiac sarcoplasmic reticulum. Biochem Biophys Res Commun. 1996 Dec 4;229(1):154-7.
Chemical & Physical Properties
Density
1.1±0.1 g/cm3
Boiling Point
185.5±9.0 °C at 760 mmHg
Melting Point
75-78 °C(lit.)
Molecular Formula
C4H7NO2
Molecular Weight
101.104
Flash Point
66.0±18.7 °C
Exact Mass
101.047676
PSA
49.66000
LogP
-0.47
Vapour Pressure
0.3±0.7 mmHg at 25°C
Index of Refraction
1.452
InChIKey
FSEUPUDHEBLWJY-UHFFFAOYSA-N
SMILES
CC(=O)C(C)=NO
Stability
Stable. Incompatible with strong oxidizing agents.
Water Solubility
5 g/100 mL (20 ºC)
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
EK3150000
CHEMICAL NAME :
2,3-Butanedione, monooxime
CAS REGISTRY NUMBER :
57-71-6
BEILSTEIN REFERENCE NO. :
0605582
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C4-H7-N-O2
MOLECULAR WEIGHT :
101.12
WISWESSER LINE NOTATION :
QNUY1&V1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
51 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6850 mg/kg/23D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 119,522,1957 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0440 No. of Facilities: 718 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4820 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0440 No. of Facilities: 370 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1974 (estimated) No. of Female Employees: 1730 (estimated)
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
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