CAS 118021-35-5|L-4-Oxalysine (hydrochloride)

Introduction：Basic information about CAS 118021-35-5|L-4-Oxalysine (hydrochloride), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. L-4-Oxalysine (hydrochloride) BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	L-4-Oxalysine (hydrochloride)
CAS Number	118021-35-5	Molecular Weight	184.62100
Density	/	Boiling Point	359.7ºC at 760mmHg
Molecular Formula	C₅H₁₃ClN₂O₃	Melting Point	212-216ºC(lit.)
MSDS	/	Flash Point	171.4ºC

Names

Name	(2S)-2-amino-3-(2-aminoethoxy)propanoic acid,hydrochloride
Synonym	More Synonyms

L-4-Oxalysine (hydrochloride) BiologicalActivity

Description	L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities.
Related Catalog	Signaling Pathways >>Anti-infection >>FungalResearch Areas >>CancerResearch Areas >>Infection
In Vitro	Alpha-fetoprotein (AFP) is expressed in BEL-7404 human hepatoma cells and L-4-Oxalysine suppresses AFP mRNA expression in the cells[1]. L-4-oxalysine functionally antagonizes the a-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor[2].
In Vivo	Tbe ultrastructural efects of different doses of L-4-Oxalysine on hepatocytes in mice are most serious at day 1 after stopping treatment. Mice are given ig L-4-oxalysine (I-677) 10, 50, and 100 mg/kg for 7 d. On day 8 the hepatocytes show accumulation of lipid droplets followed by loss of matrices in cytoplasm. The total area of lipid droplets is far less than 25% of mean section of hepatocytes. The injury of mitochondria and RER is only found in the groups of medium and high dose[1]. L-4-oxalysine inhibits the proliferation of some mouse implanted tumors and pulmonary metastasis of mouse Lewis lung carcinoma[2].
Animal Admin	Mice: Sixty mice are randomly and equally divided into 4 groups. One of the groups is given ig saline and the other are given ig 10, 50, 100 mg /kg for 7d. On day l, 7, 14, and 28 respectively after terminating the treatment, 3 mice of each group are killed and the samples are examined under transmission electron microscope[1].
References	[1]. Dai ZQ, et al. Effect of L-4-oxalysine on ultrastructures of liver cells in mice. Zhongguo Yao Li Xue Bao. 1991 Jul;12(4):336-40. [2]. Wang XW, et al. Immunostimulatory action of L-4-oxalysine counteracts immunosuppression induced by alpha-fetoprotein. Eur J Pharmacol. 1998 Jun 12;351(1):105-11.

Chemical & Physical Properties

Boiling Point	359.7ºC at 760mmHg
Melting Point	212-216ºC(lit.)
Molecular Formula	C₅H₁₃ClN₂O₃
Molecular Weight	184.62100
Flash Point	171.4ºC
Exact Mass	184.06100
PSA	98.57000
LogP	0.57620
Vapour Pressure	3.77E-06mmHg at 25°C
InChIKey	OVHJSRSTAWFIIF-WCCKRBBISA-N
SMILES	Cl.NCCOCC(N)C(=O)O

Safety Information

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26
WGK Germany	3

Synonyms

(S)-(+)-2-Amino-3-(2-aminoethoxy)propanoic acid monohydrochloride

O-2-aminoethylserine dihydrochloride

O-(2-Amino-aethyl)-serin,Dihydrochlorid

4-oxalysine dihydrochloride

DL-4-Oxalysine dihydrochloride

O-(2-aminoethyl)-l-serine hydrochloride

MFCD01631149

L-4-Oxalysine (hydrochloride)

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