CAS 300816-11-9|script

Introduction：Basic information about CAS 300816-11-9|script, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. script BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	script
CAS Number	300816-11-9	Molecular Weight	298.293
Density	1.4±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₁₆H₁₄N₂O₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	4-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxybutanamide
Synonym	More Synonyms

script BiologicalActivity

Description	Nullscript is a negative control for Scriptaid. Nullscript is a known inactive analog of Scriptaid[1]. Scriptaid is a representative HDAC inhibitor[2]. Nullscript inhibits Cryptosporidium (C. parvum) growth with the IC50 value of 2.1 μM[3].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>HDACSignaling Pathways >>Epigenetics >>HDAC
References	[1]. Min Tong, et al. Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells. Biochem Pharmacol. 2006 Sep 14;72(6):701-9. [2]. Judith Clancy Keen, et al. A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine. Breast Cancer Res Treat. 2003 [3]. Fumi Murakoshi, et al. Nullscript inhibits Cryptosporidium and Toxoplasma growth. Int J Parasitol Drugs Drug Resist. 2020 Dec;14:159-166.

Description

Nullscript is a negative control for Scriptaid. Nullscript is a known inactive analog of Scriptaid[1]. Scriptaid is a representative HDAC inhibitor[2]. Nullscript inhibits Cryptosporidium (C. parvum) growth with the IC50 value of 2.1 μM[3].

Related Catalog

Research Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>HDACSignaling Pathways >>Epigenetics >>HDAC

References

[1]. Min Tong, et al. Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells. Biochem Pharmacol. 2006 Sep 14;72(6):701-9.

[2]. Judith Clancy Keen, et al. A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine. Breast Cancer Res Treat. 2003

[3]. Fumi Murakoshi, et al. Nullscript inhibits Cryptosporidium and Toxoplasma growth. Int J Parasitol Drugs Drug Resist. 2020 Dec;14:159-166.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Molecular Formula	C₁₆H₁₄N₂O₄
Molecular Weight	298.293
Exact Mass	298.095367
PSA	88.40000
LogP	-0.10
Index of Refraction	1.676
InChIKey	GBPSCCPAXYTNMB-UHFFFAOYSA-N
SMILES	O=C(CCCN1C(=O)c2cccc3cccc(c23)C1=O)NO
Storage condition	-20°C

Safety Information

Safety Phrases	22-24/25

Synonyms

MFCD00405081

1H-Benz[de]isoquinoline-2(3H)-butanamide, N-hydroxy-1,3-dioxo-

4-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxybutanamide

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