CAS 4246-51-9|4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE
Introduction：Basic information about CAS 4246-51-9|4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE | ||
|---|---|---|---|
| CAS Number | 4246-51-9 | Molecular Weight | 220.309 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 310.6±0.0 °C at 760 mmHg |
| Molecular Formula | C10H24N2O3 | Melting Point | -32 °C |
| MSDS | ChineseUSA | Flash Point | 148.0±17.4 °C |
| Symbol | GHS05 | Signal Word | Danger |
Names
| Name | 4,7,10-Trioxa-1,13-Tridecanediamine |
|---|---|
| Synonym | More Synonyms |
4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE BiologicalActivity
| Description | PROTAC Linker 24 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 24 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | Alkyl/ether |
| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 310.6±0.0 °C at 760 mmHg |
| Melting Point | -32 °C |
| Molecular Formula | C10H24N2O3 |
| Molecular Weight | 220.309 |
| Flash Point | 148.0±17.4 °C |
| Exact Mass | 220.178696 |
| PSA | 79.73000 |
| LogP | -1.51 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.464 |
| InChIKey | JCEZOHLWDIONSP-UHFFFAOYSA-N |
| SMILES | NCCCOCCOCCOCCCN |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4290 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4290 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2500 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1067 No. of Facilities: 307 (estimated) No. of Industries: 10 No. of Occupations: 10 No. of Employees: 13486 (estimated) No. of Female Employees: 3955 (estimated)
Safety Information
| Symbol | GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H314 |
| Precautionary Statements | P280-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | C: Corrosive; |
| Risk Phrases | R34 |
| Safety Phrases | S26-S36/37/39-S45 |
| RIDADR | UN 2735 8/PG 3 |
| WGK Germany | 2 |
| RTECS | ID6475000 |
| Packaging Group | III |
| Hazard Class | 8 |
| HS Code | 2922199090 |
Customs
| HS Code | 2922199090 |
|---|---|
| Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles3
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Synonyms
| 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE |
| 3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propan-1-amine |
| 3,3'-[OXYBIS(ETHANE-2,1-DIYLOXY)]DIPROPAN-1-AMINE |
| Diethylene Glycol Bis(3-aMinopropyl) Ether |
| EINECS 224-207-2 |
| MFCD00059850 |
| 3,3'-[Oxybis(2,1-ethanediyloxy)]di(1-propanamine) |
| 1-Propanamine, 3,3'-[oxybis(2,1-ethanediyloxy)]bis- |
| 3,3'-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine) |
| Bis[2-(3-aminopropoxy)ethyl] Ether |
