CAS 917-13-5|Enniatin B
Introduction：Basic information about CAS 917-13-5|Enniatin B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Enniatin B | ||
|---|---|---|---|
| CAS Number | 917-13-5 | Molecular Weight | 639.820 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 827.0±65.0 °C at 760 mmHg |
| Molecular Formula | C33H57N3O9 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 454.0±34.3 °C |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | enniatin B |
|---|---|
| Synonym | More Synonyms |
Enniatin B BiologicalActivity
| Description | Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes[1]. Enniatins B decreases the activation of ERK (p44/p42)[2]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseResearch Areas >>InfectionSignaling Pathways >>MAPK/ERK Pathway >>ERKSignaling Pathways >>Metabolic Enzyme/Protease >>AcyltransferaseSignaling Pathways >>Stem Cell/Wnt >>ERK |
| Target | ACAT ERK |
| References | [1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32. [2]. Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 827.0±65.0 °C at 760 mmHg |
| Molecular Formula | C33H57N3O9 |
| Molecular Weight | 639.820 |
| Flash Point | 454.0±34.3 °C |
| Exact Mass | 639.409485 |
| PSA | 139.83000 |
| LogP | 3.05 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.460 |
| InChIKey | MIZMDSVSLSIMSC-VYLWARHZSA-N |
| SMILES | CC(C)C1OC(=O)C(C(C)C)N(C)C(=O)C(C(C)C)OC(=O)C(C(C)C)N(C)C(=O)C(C(C)C)OC(=O)C(C(C)C)N(C)C1=O |
| Storage condition | ?20°C |
| Water Solubility | DMSO: soluble10mg/mL |
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H311-H331 |
| Precautionary Statements | P261-P280-P301 + P310-P311 |
| Hazard Codes | T |
| Risk Phrases | 23/24/25 |
| Safety Phrases | 45 |
| RIDADR | UN 2811 |
| Packaging Group | I |
| Hazard Class | 6.1(a) |
Articles1
More Articles| An investigation of the endocrine disrupting potential of enniatin B using in vitro bioassays. Toxicol. Lett. , doi:10.1016/j.toxlet.2015.01.014, (2015) Evidence that some of the fungal metabolites present in food and feed may act as potential endocrine disruptors is increasing. Enniatin B (ENN B) is among the emerging Fusarium mycotoxins known to con... |
Synonyms
| enniatin b |
| 1,7,13-Trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone, 4,10,16-trimethyl-3,6,9,12,15,18-hexakis(1-methylethyl)-, (3S,6R,9S,12R,15S,18R)- |
| (3S,6R,9S,12R,15S,18R)-3,6,9,12,15,18-Hexaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone |
