Introduction：Basic information about CAS 125926-17-2|Sarpogrelate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sarpogrelate |
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| CAS Number | 125926-17-2 | Molecular Weight | 429.506 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 585.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C24H31NO6 | Melting Point | / |
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| MSDS | / | Flash Point | 308.1±30.1 °C |
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Names
| Name | 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid |
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| Synonym | More Synonyms |
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Sarpogrelate BiologicalActivity
| Description | Sarpogrelate (MCI-9042) is a new, specific orally active 5-HT2 receptor antagonist, Sarpogrelate (MCI-9042) increases platelet aggregation and has hemostasis effect, and can be used for the research of Buerger’s disease[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| Target | 5-HT2 Receptor |
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| In Vitro | Sarpogrelate (MCI-9042) induces a significant decrease in plasma serotonin (5-HT) concentration and after 2 weeks increases significantly the concentration of whole blood 5-HT. Sarpogrelate (MCI-9042) increases significantly plasma tryptophan concentration after 2 and 4 weeks, and no changes in plasma 5-HIAA concentration. Sarpogrelate (MCI-9042) also has a tendency to increase the concentration of whole blood tryptophan concentration, did not show significant changes in platelet aggregation induced by ADP and collagen. Sarpogrelate (MCI-9042) increases significantly platelet aggregation induced by serotonin after 2 weeks[1]. |
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| References | [1]. A Rydzewski, et al. The effect of a 5HT2 receptor antagonist sarpogrelate (MCI-9042) treatment on platelet function in Buerger's disease. Thromb Res. 1996 Dec 15;84(6):445-52. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 585.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C24H31NO6 |
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| Molecular Weight | 429.506 |
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| Flash Point | 308.1±30.1 °C |
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| Exact Mass | 429.215149 |
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| PSA | 85.30000 |
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| LogP | 3.68 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.551 |
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| InChIKey | FFYNAVGJSYHHFO-UHFFFAOYSA-N |
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| SMILES | COc1cccc(CCc2ccccc2OCC(CN(C)C)OC(=O)CCC(=O)O)c1 |
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Synonyms
| UNII-19P708E787 |
| Sarpogrelate Hydrochloride |
| Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester |
| 4-{[1-(Dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}-2-propanyl]oxy}-4-oxobutanoic acid |
| Sarpogrelate |
