CAS 4033-27-6|Dihydrofolic acid
Introduction：Basic information about CAS 4033-27-6|Dihydrofolic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dihydrofolic acid | ||
|---|---|---|---|
| CAS Number | 4033-27-6 | Molecular Weight | 443.41300 |
| Density | 1.69g/cm3 | Boiling Point | / |
| Molecular Formula | C19H21N7O6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | dihydrofolic acid |
|---|---|
| Synonym | More Synonyms |
Dihydrofolic acid BiologicalActivity
| Description | Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. |
|---|---|
| Related Catalog | Research Areas >>OthersNatural Products >>Others |
| Target | Human Endogenous Metabolite |
Chemical & Physical Properties
| Density | 1.69g/cm3 |
|---|---|
| Molecular Formula | C19H21N7O6 |
| Molecular Weight | 443.41300 |
| Exact Mass | 443.15500 |
| PSA | 211.89000 |
| LogP | 0.62870 |
| Index of Refraction | 1.762 |
| InChIKey | OZRNSSUDZOLUSN-LBPRGKRZSA-N |
| SMILES | Nc1nc2c(c(=O)[nH]1)N=C(CNc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)CN2 |
| Storage condition | -20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
Articles34
More Articles| Synthetic polyglutamylation of dual-functional MTX ligands for enhanced combined cytotoxicity of poly(I:C) nanoplexes. Mol. Pharm. 11(8) , 2631-9, (2014) The antifolate drug methotrexate (MTX) can serve as a dual-functional ligand in antitumoral drug delivery, inducing both a folate receptor mediated cellular uptake and an intracellular cytotoxic actio... | |
| A domino effect in antifolate drug action in Escherichia coli. Nat. Chem. Biol. 4 , 602-8, (2008) Mass spectrometry technologies for measurement of cellular metabolism are opening new avenues to explore drug activity. Trimethoprim is an antibiotic that inhibits bacterial dihydrofolate reductase (D... | |
| Methotrexate-gelonin conjugate - an inhibitor of MCF-7 cells expressing the dihydrofolate receptor. Biol. Chem. 395(12) , 1461-6, (2014) An immunotoxin composed of gelonin, a basic ribosome-inactivating protein, type I of 30 kDa, isolated from the seeds of the Indian plant Gelonium multiflorum and methotrexate (MTX) has been studied as... |
Synonyms
| 7,8-Dihydropteroyl-L-glutamic acid Dihydropteroyl-L-glutamic acid |
| DIHYDROFOLIC ACID |
