CAS 4044-65-9|p-Phenylene diisothiocyanate
Introduction：Basic information about CAS 4044-65-9|p-Phenylene diisothiocyanate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | p-Phenylene diisothiocyanate | ||
|---|---|---|---|
| CAS Number | 4044-65-9 | Molecular Weight | 192.26100 |
| Density | 1.2g/cm3 | Boiling Point | 339.4ºC at 760 mmHg |
| Molecular Formula | C8H4N2S2 | Melting Point | 129-131 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 167.2ºC |
| Symbol | GHS06, GHS08 | Signal Word | Danger |
Names
| Name | 1,4-phenylene diisothiocyanate |
|---|---|
| Synonym | More Synonyms |
p-Phenylene diisothiocyanate BiologicalActivity
| Description | Bitoscanate (p-Phenylene diisothiocyanate) is an organic chemical compound used in the treatment of hookworms. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection |
| References | [1]. Gaitonde BB, et al. Clinical evaluation of a new anthelmintic; phenylene di-iso thiocyanate (Bitoscanate) in hookworm and roundworm infestation. J Trop Med Hyg. 1969 Oct;72(10):253-8. |
Chemical & Physical Properties
| Density | 1.2g/cm3 |
|---|---|
| Boiling Point | 339.4ºC at 760 mmHg |
| Melting Point | 129-131 °C(lit.) |
| Molecular Formula | C8H4N2S2 |
| Molecular Weight | 192.26100 |
| Flash Point | 167.2ºC |
| Exact Mass | 191.98200 |
| PSA | 88.90000 |
| LogP | 3.15520 |
| Vapour Pressure | 0.000182mmHg at 25°C |
| Index of Refraction | 1.641 |
| InChIKey | OMWQUXGVXQELIX-UHFFFAOYSA-N |
| SMILES | S=C=Nc1ccc(N=C=S)cc1 |
| Storage condition | −20°C |
| Water Solubility | chloroform: clear |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 3 mg/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Gastrointestinal - nausea or vomiting
- REFERENCE :
- JTMHA9 Journal of Tropical Medicine and Hygiene. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.10- 1907- Volume(issue)/page/year: 72,253,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JTMHA9 Journal of Tropical Medicine and Hygiene. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.10- 1907- Volume(issue)/page/year: 72,253,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973
Safety Information
| Symbol | GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H315-H319-H334-H335 |
| Precautionary Statements | P261-P301 + P310-P305 + P351 + P338-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful;Xi: Irritant; |
| Risk Phrases | R22 |
| Safety Phrases | S22-S26-S36/37 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | NX9150000 |
| Packaging Group | II |
| Hazard Class | 6.1 |
| HS Code | 2930909090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles11
More Articles| Label-free impedimetric immunosensor for ultrasensitive detection of cancer marker Murine double minute 2 in brain tissue. Biosens. Bioelectron. 39(1) , 220-5, (2013) The detection of cancer biomarkers is as important tool for the diagnosis and prognosis of cancer such as brain cancer. Murine double minute 2 (MDM2) has been widely studied as prognostic marker for b... | |
| Optimizing the immobilization of single-stranded DNA onto glass beads. J. Biochem. Biophys. Methods 47(3) , 221-31, (2001) The attachment of single-stranded DNA to a solid support has many biotechnology and molecular biology applications. This paper compares different immobilization chemistries to covalently link single-s... | |
| Barcoded nucleotides. Angew. Chem. Int. Ed. Engl. 51(1) , 254-7, (2012) |
Synonyms
| Bitoscanate |
| EINECS 223-741-3 |
| 1,4-Diisothiocyanatobenzene,Bitoscanate,PDITC |
| p-Phenylene diisothiocyanate |
| MFCD00004811 |
| Benzene 1,4-Diisothiocyanate |
| 1,4-Diisothiocyanatobenzene |
| 1,4-Phenylene Diisothiocyanate |
