Introduction：Basic information about CAS 116289-53-3|Tulopafant, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tulopafant |
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| CAS Number | 116289-53-3 | Molecular Weight | 425.50200 |
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| Density | 1.32g/cm3 | Boiling Point | 613.3ºC at 760mmHg |
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| Molecular Formula | C25H19N3O2S | Melting Point | / |
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| MSDS | / | Flash Point | 324.7ºC |
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Names
| Name | N-(3-benzoylphenyl)-3-pyridin-3-yl-1,3-dihydropyrrolo[1,2-c][1,3]thiazole-7-carboxamide |
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| Synonym | More Synonyms |
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Tulopafant BiologicalActivity
| Description | Tulopafant is a platelet activating factor (PAF) antagonist. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease |
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| In Vitro | Preincubation of neutrophils with Tulopafant (RP 59227) results in a concentration-dependent decrease in chemiluminescence produced by PAF primed cells[1]. |
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| In Vivo | Tulopafant (RP 59227) effectively reduces myocardial infarct size and reduces the incidence of ischemia and reperfusion-induced arrhythmias in barbital-anesthetized dogs[1].Histological examination reveals marked diminution of both interstitial hemorrhage and deposition of platelet and granulocytes in capillaries of cardiac xenografts when recipient animals are pretreated with Tulopafant[2]. |
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| References | [1]. Auchampach JA, et al. Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. Basic Res Cardiol. 1998 Oct;93(5):361-71. [2]. O'Hair DP, et al. Tulopafant, a PAF receptor antagonist, increases capillary patency and prolongs survival in discordant cardiac xenotransplants. J Lipid Mediat. 1993 May;7(1):79-84. |
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Chemical & Physical Properties
| Density | 1.32g/cm3 |
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| Boiling Point | 613.3ºC at 760mmHg |
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| Molecular Formula | C25H19N3O2S |
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| Molecular Weight | 425.50200 |
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| Flash Point | 324.7ºC |
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| Exact Mass | 425.12000 |
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| PSA | 89.29000 |
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| LogP | 5.23310 |
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| Vapour Pressure | 5.63E-15mmHg at 25°C |
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| Index of Refraction | 1.702 |
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| InChIKey | PQQFNXGONTVQLM-UHFFFAOYSA-N |
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| SMILES | O=C(c1ccccc1)c1cccc(NC(=O)c2ccn3c2CSC3c2cccnc2)c1 |
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| Storage condition | 2-8℃ |
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Synonyms
| Tulopafant |
| Tulopafantum |
| UNII-IQ3Q8N1287 |
