CAS 155206-00-1|Bimatoprost

Introduction：Basic information about CAS 155206-00-1|Bimatoprost, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Bimatoprost BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles28
6. Synonyms

Common Name	Bimatoprost
CAS Number	155206-00-1	Molecular Weight	415.566
Density	1.1±0.1 g/cm3	Boiling Point	629.8±55.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₇NO₄	Melting Point	66-68°C
MSDS	USA	Flash Point	334.7±31.5 °C

Names

Name	bimatoprost
Synonym	More Synonyms

Bimatoprost BiologicalActivity

Description	Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.Target: Prostaglandin ReceptorBimatoprost is a prostaglandin analog/prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. In December 2008, the indication to lengthen eyelashes was approved by the U.S. Food and Drug Administration (FDA); the cosmetic formulation of bimatoprost is sold as Latisse. In 2008-2011, at least three case series suggested that bimatoprost has the ability to reduce adipose (fat) tissue.Bimatoprost activates prostamide alpha F2 receptors found in the hair follicle to stimulate its growth rate. Research led by Professor Randall and the University of Bradford found that it may also offer a treatment for scalp hair regrowth in trials conducted on samples taken from men undergoing hair transplants. According to Allergan's package labeling, users of its Latisse cosmetic product didn't develop darker irises in clinical studies; however, "patients should be advised about the potential for increased brown iris pigmentation which is likely to be permanent."
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorResearch Areas >>Others
References	[1]. Park J, et al. Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost. Jpn J Ophthalmol. 2011 Jan;55(1):22-7. [2]. Filippopoulos T, et al. Periorbital changes associated with topical bimatoprost. Ophthal Plast Reconstr Surg. 2008 Jul-Aug;24(4):302-7.

Description

Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.Target: Prostaglandin ReceptorBimatoprost is a prostaglandin analog/prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. In December 2008, the indication to lengthen eyelashes was approved by the U.S. Food and Drug Administration (FDA); the cosmetic formulation of bimatoprost is sold as Latisse. In 2008-2011, at least three case series suggested that bimatoprost has the ability to reduce adipose (fat) tissue.Bimatoprost activates prostamide alpha F2 receptors found in the hair follicle to stimulate its growth rate. Research led by Professor Randall and the University of Bradford found that it may also offer a treatment for scalp hair regrowth in trials conducted on samples taken from men undergoing hair transplants. According to Allergan's package labeling, users of its Latisse cosmetic product didn't develop darker irises in clinical studies; however, "patients should be advised about the potential for increased brown iris pigmentation which is likely to be permanent."

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorResearch Areas >>Others

References

[1]. Park J, et al. Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost. Jpn J Ophthalmol. 2011 Jan;55(1):22-7.

[2]. Filippopoulos T, et al. Periorbital changes associated with topical bimatoprost. Ophthal Plast Reconstr Surg. 2008 Jul-Aug;24(4):302-7.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	629.8±55.0 °C at 760 mmHg
Melting Point	66-68°C
Molecular Formula	C₂₅H₃₇NO₄
Molecular Weight	415.566
Flash Point	334.7±31.5 °C
Exact Mass	415.272247
PSA	89.79000
LogP	1.98
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.591
InChIKey	AQOKCDNYWBIDND-UDIRQSBCSA-N
SMILES	CCNC(=O)CCCC=CCC1C(O)CC(O)C1C=CC(O)CCc1ccccc1
Storage condition	−20°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3

Articles28

A retrospective review and observational study of outcomes and safety of bimatoprost ophthalmic solution 0.03% for treating eyelash hypotrichosis.

Dermatol. Surg. 40(10) , 1118-24, (2014)

The efficacy and safety of bimatoprost ophthalmic solution 0.03% for treating hypotrichosis were shown in a randomized controlled trial and in an open-label study. To date, no data on real-world exper...

Conjunctiva-associated lymphoid tissue (CALT) reactions to antiglaucoma prostaglandins with or without BAK-preservative in rabbit acute toxicity study.

PLoS ONE 7 , e33913, (2012)

Conjunctiva-associated lymphoid tissue (CALT) is closely associated with ocular surface immunity. This study investigated the effects of antiglaucoma prostaglandin analogs with or without benzalkonium...

Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes.

Mol. Vis. 18 , 431-8, (2012)

To determine the proinflammatory cytokine profile of aqueous humor from glaucomatous eyes.Aqueous humor samples were prospectively collected from 38 eyes (26 primary open angle glaucoma [POAG] and 12 ...

Synonyms

(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl}-N-ethyl-5-heptenamide

BiMatoprost HOUSE STANDARD

BiMapnost

(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide

Prostamide

17-Phenyl-tri-norprostaglandin F2α-ethyl amide

MFCD03411999

5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-, (5Z)-

Lumigan

Bimatoprost

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