Introduction：Basic information about CAS 191330-56-0|Ezetimibe Ketone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ezetimibe Ketone |
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| CAS Number | 191330-56-0 | Molecular Weight | 407.409 |
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| Density | 1.325 | Boiling Point | 656.1±55.0 °C at 760 mmHg |
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| Molecular Formula | C24H19F2NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 350.6±31.5 °C |
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Names
| Name | (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one |
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| Synonym | More Synonyms |
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Ezetimibe Ketone BiologicalActivity
| Description | Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor[1][2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>NF-κB >>Keap1-Nrf2Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Autophagy >>Autophagy |
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| Target | NPC1L1, Nrf2[1] |
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| References | [1]. Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. Synthetic Communications. 2016, 46:20, 1687-1693. [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [3]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63. |
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Chemical & Physical Properties
| Density | 1.325 |
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| Boiling Point | 656.1±55.0 °C at 760 mmHg |
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| Molecular Formula | C24H19F2NO3 |
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| Molecular Weight | 407.409 |
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| Flash Point | 350.6±31.5 °C |
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| Exact Mass | 407.133301 |
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| PSA | 57.61000 |
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| LogP | 3.79 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.615 |
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| InChIKey | UEPZDXMEEKCJSP-FYYLOGMGSA-N |
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| SMILES | O=C(CCC1C(=O)N(c2ccc(F)cc2)C1c1ccc(O)cc1)c1ccc(F)cc1 |
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Safety Information
Synonyms
| 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl)-propyl]-4-(S)-(4-hydroxyphenyl)azetidin-2-one |
| 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3-oxopropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone |
| (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxo-propyl]-4-(4-hydroxyphenyl)-2-azetidinone |
| AZE016 |
| (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone |
| (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one |
| 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl)propyl]-4-(S)-(4-hydroxyphenyl)-2-azetidinone |
| 2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-, (3R,4S)- |
| (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-azetidin-2-one |
| Ezetimibe Intermediate-X |
| EzetiMibe Ketone |
| Ezetimibe Impurity 12 |
