Introduction：Basic information about CAS 1508-76-5|Procyclidine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Procyclidine hydrochloride |
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| CAS Number | 1508-76-5 | Molecular Weight | 323.90100 |
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| Density | / | Boiling Point | 433.5ºC at 760 mmHg |
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| Molecular Formula | C19H30ClNO | Melting Point | 85.5 to 86.5ºC |
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| MSDS | USA | Flash Point | 205.7ºC |
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Names
| Name | procyclidine hydrochloride |
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| Synonym | More Synonyms |
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Procyclidine hydrochloride BiologicalActivity
| Description | Procyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>iGluRSignaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological Disease |
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| Target | NMDA Receptor[1] |
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| In Vivo | Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain[1]. |
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| Animal Admin | Rats[1] Adult Sprague-Dawley female rats (weight 300-330 g) are used. Procyclidine given systemically causes a transient increase in locomotor activity (mainly non-ambulatory fine movements) in adult rats. Locomotor activity data (ambulations, fine movements) are evaluated using a two-way ANOVA to test whether co-administration of clonidine (0.025 mg/kg) with various doses of Procyclidine (10, 25, 50 and 75 mg/kg) altered the activity levels compared to the same doses of Procyclidine administered alone. A one-way ANOVA and subsequent comparisons are also conducted to establish whether the activity levels for each treatment group are different from saline controls. |
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| References | [1]. Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48. |
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Chemical & Physical Properties
| Boiling Point | 433.5ºC at 760 mmHg |
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| Melting Point | 85.5 to 86.5ºC |
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| Molecular Formula | C19H30ClNO |
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| Molecular Weight | 323.90100 |
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| Flash Point | 205.7ºC |
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| Exact Mass | 323.20200 |
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| PSA | 23.47000 |
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| LogP | 4.68030 |
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| Vapour Pressure | 2.76E-08mmHg at 25°C |
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| InChIKey | ZFSPFXJSEHCTTR-UHFFFAOYSA-N |
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| SMILES | Cl.OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1 |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UY1926000
- CHEMICAL NAME :
- 1-Pyrrolidinepropanol, alpha-cyclohexyl-alpha-phenyl-, monohydrochloride
- CAS REGISTRY NUMBER :
- 1508-76-5
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C19-H29-N-O.Cl-H
- MOLECULAR WEIGHT :
- 323.95
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 55 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 103,100,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5608 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)
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Safety Information
| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | 36 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | UY1926000 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Procyclidine hydrochloride |
| Procyclidine Hydrochloride |
| PROCYCLIDINE HYDROCHLORIDE |
