CAS 87691-91-6|Tiospirone

Introduction：Basic information about CAS 87691-91-6|Tiospirone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tiospirone BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Tiospirone
CAS Number	87691-91-6	Molecular Weight	440.60100
Density	1.29g/cm3	Boiling Point	600.9ºC at 760 mmHg
Molecular Formula	C₂₄H₃₂N₄O₂S	Melting Point	/
MSDS	/	Flash Point	317.2ºC

Names

Name	8-[4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl]-8-azaspiro[4.5]decane-7,9-dione
Synonym	More Synonyms

Tiospirone BiologicalActivity

Description	Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm[1][2].
Related Catalog	Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor
References	[1]. Arolfo MP, et, al. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiol Behav. 1999 Dec;68(1-2):93-8. [2]. Arolfo MP, et, al. Tiospirone and the reinforcing effects of cocaine in the conditioned place preference paradigm in rats. J Pharm Pharmacol. 2000 Aug;52(8):977-81.

Description

Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm[1][2].

Related Catalog

Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor

References

[1]. Arolfo MP, et, al. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiol Behav. 1999 Dec;68(1-2):93-8.

[2]. Arolfo MP, et, al. Tiospirone and the reinforcing effects of cocaine in the conditioned place preference paradigm in rats. J Pharm Pharmacol. 2000 Aug;52(8):977-81.

Chemical & Physical Properties

Density	1.29g/cm3
Boiling Point	600.9ºC at 760 mmHg
Molecular Formula	C₂₄H₃₂N₄O₂S
Molecular Weight	440.60100
Flash Point	317.2ºC
Exact Mass	440.22500
PSA	84.99000
LogP	3.84870
Index of Refraction	1.652
InChIKey	ZFZPJDFBJFHYIV-UHFFFAOYSA-N
SMILES	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2nsc3ccccc23)CC1

Synonyms

Tiospirona [Spanish]

tiaspirone

Tiospirone [INN]

Tiospironum [Latin]

[14C]-Tiospirone

Tiospironum

Tiospirona

8-{4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl}-8-azaspiro[4.5]decane-7,9-dione

8-Azaspiro(4,5)decane-7,9-dione,8-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)

TIOSPIRONE

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