Introduction：Basic information about CAS 59110-35-9|Pamatolol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pamatolol |
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| CAS Number | 59110-35-9 | Molecular Weight | 310.38900 |
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| Density | 1.103g/cm3 | Boiling Point | 487ºC at 760 mmHg |
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| Molecular Formula | C16H26N2O4 | Melting Point | / |
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| MSDS | / | Flash Point | 248.3ºC |
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Names
| Name | methyl N-[2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethyl]carbamate |
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| Synonym | More Synonyms |
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Pamatolol BiologicalActivity
| Description | Pamatolol is a cardioselective beta-adrenoceptor antagonist without sympathomimetic activity. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Cardiovascular Disease |
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| In Vivo | Pamatolol is well absorbed in the gastro-intestinal tract and excreted in the urine of man, dogs, rats and mice after oral administration, mainly in unchanged form, within 24 hrs[1]. |
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| Animal Admin | Three male Sprague-Dawley rats weighing 200-250 g are given pamatolol-sulphate dissolved in water at a dose of 50 mg/kg (10 μCi/mg) by means of a stomach tube. The rats are housed in metabolic cages that allows for separate collection of urine and feces for a 24 hr period. They are given a commercial pellet diet and drinking water ad libitum. |
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| References | [1]. Hoffmann KJ, et al. Species differences in the metabolism of pamatolol, a cardioselective beta--adrenoceptor antagonist. Eur J Drug Metab Pharmacokinet. 1979;4(3):163-73. |
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Chemical & Physical Properties
| Density | 1.103g/cm3 |
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| Boiling Point | 487ºC at 760 mmHg |
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| Molecular Formula | C16H26N2O4 |
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| Molecular Weight | 310.38900 |
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| Flash Point | 248.3ºC |
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| Exact Mass | 310.18900 |
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| PSA | 79.82000 |
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| LogP | 2.10460 |
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| Index of Refraction | 1.518 |
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| InChIKey | UGENBJKPPGFFAT-UHFFFAOYSA-N |
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| SMILES | COC(=O)NCCc1ccc(OCC(O)CNC(C)C)cc1 |
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| Storage condition | 2-8℃ |
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Synonyms
| Pamatolol [INN] |
| Pamatololum [INN-Latin] |
| Pamatololum |
| UNII-20G2S6V53L |
| Pamatolol |
| Methyl N-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenethyl)carbamat |
