CAS 145414-76-2|6',7'-DIHYDROXYBERGAMOTTIN

Introduction：Basic information about CAS 145414-76-2|6',7'-DIHYDROXYBERGAMOTTIN, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 6',7'-DIHYDROXYBERGAMOTTIN BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles1
6. Synonyms

Common Name	6',7'-DIHYDROXYBERGAMOTTIN
CAS Number	145414-76-2	Molecular Weight	370.396
Density	1.3±0.1 g/cm3	Boiling Point	611.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₂O₆	Melting Point	112-113 °C
MSDS	ChineseUSA	Flash Point	323.5±31.5 °C

Names

Name	6´,-7´-Dihydroxybergamottin
Synonym	More Synonyms

6',7'-DIHYDROXYBERGAMOTTIN BiologicalActivity

Description	6',7'-Dihydroxybergamottin (6′,7′-DHB) is a furanocoumarin that inhibits CYP3A4 and is found in grapefruit juice and Seville orange juice[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450
Target	CYP3A4
References	[1]. D J Edwards, et al. 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther. 1999 Mar;65(3):237-44.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	611.3±55.0 °C at 760 mmHg
Melting Point	112-113 °C
Molecular Formula	C₂₁H₂₂O₆
Molecular Weight	370.396
Flash Point	323.5±31.5 °C
Exact Mass	370.141632
PSA	93.04000
LogP	5.57
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.633
InChIKey	IXZUPBUEKFXTSD-MDWZMJQESA-N
SMILES	CC(=CCOc1c2ccoc2cc2oc(=O)ccc12)CCC(O)C(C)(C)O

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Articles1

Grapefruit juice, lyophilized grapefruit juice, and powdered whole grapefruit inhibit cytochrome P450-mediated triazolam hydroxylation by beagle dog liver microsomes.

J. Vet. Pharmacol. Ther. 33(2) , 189-95, (2010)

Coadministration of grapefruit juice (GFJ) has been proposed to enhance the systemic availability and decrease the required dose of drugs such as cyclosporine that are extensively metabolized in the i...

Synonyms

7H-Furo[3,2-g][1]benzopyran-7-one, 5-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-2,3-dihydroxy-

6',7'-Dihydroxy Bergamottin

5-{[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]oxy}-2,3-dihydroxy-7H-furo[3,2-g]chromen-7-one

Recommended......