CAS 217082-58-1|Apelin 13

Introduction：Basic information about CAS 217082-58-1|Apelin 13, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Apelin 13 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Apelin 13
CAS Number	217082-58-1	Molecular Weight	1550.829
Density	1.5±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₆₉H₁₁₁N₂₃O₁₆S	Melting Point	/
MSDS	ChineseUSA	Flash Point	/

Names

Name	gln-arg-pro-arg-leu-ser-his-lys-gly-pro-met-pro-phe
Synonym	More Synonyms

Apelin 13 BiologicalActivity

Description	Apelin-13 is the endogenous ligand of the orphan G protein-coupled receptor APJ, activates APJ receptor with an EC50 value of 0.37 nM in CHO cells[1][2].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
References	[1]. Tatemoto, K., Hosoya, M., Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and Biophysical Research Communications 251, 471-476 (1998). [2]. Li M,et al. Apelin 13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high fat diet. Mol Med Rep. 2018 Dec;18(6):5784-5790.

Description

Apelin-13 is the endogenous ligand of the orphan G protein-coupled receptor APJ, activates APJ receptor with an EC50 value of 0.37 nM in CHO cells[1][2].

Related Catalog

Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease

References

[1]. Tatemoto, K., Hosoya, M., Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and Biophysical Research Communications 251, 471-476 (1998).

[2]. Li M,et al. Apelin 13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high fat diet. Mol Med Rep. 2018 Dec;18(6):5784-5790.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Molecular Formula	C₆₉H₁₁₁N₂₃O₁₆S
Molecular Weight	1550.829
Exact Mass	1549.829956
PSA	653.27000
LogP	-3.42
Index of Refraction	1.688
InChIKey	XXCCRHIAIBQDPX-UHFFFAOYSA-N
SMILES	CSCCC(NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(N)CCC(N)=O)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O
Storage condition	−20°C
Water Solubility	Soluble in PBS (pH 7.2) at approximately 10 mg/ml.

Safety Information

WGK Germany	3

Synonyms

APELIN-13

L-Phenylalanine, L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-

Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe ((2) Due to the presence of a Gln in N-terMinal position this peptide can contain the pyroglutaMic forM)

APELIN-13 (HUMAN,BOVINE,MOUSE,RAT)

Apelin-13,human,bovine,mouse,rat (2)

APELIN-13 (HUMAN,BOVINE)

L-Glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine

apelin-13 trifluoroacetate salt

QRPRLSHKGPMPF

PREPRO-65-77-APELIN

MFCD02094627

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