CAS 118292-41-4|Tazarotenic Acid

Introduction：Basic information about CAS 118292-41-4|Tazarotenic Acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tazarotenic Acid BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Tazarotenic Acid
CAS Number	118292-41-4	Molecular Weight	323.409
Density	1.3±0.1 g/cm3	Boiling Point	527.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₇NO₂S	Melting Point	/
MSDS	/	Flash Point	272.9±30.1 °C

Names

Name	tazarotenic acid
Synonym	More Synonyms

Tazarotenic Acid BiologicalActivity

Description	Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma[1][2][3].
Related Catalog	Research Areas >>Others
In Vivo	Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats[1] . Male Female Male Dose (mg kg-1) 4.4 4.4 0.49 AUC (μg h mL-1) 9.31 (2.14) 9.78 (1.36) 0.594 (0.95) CL (mL min-1 kg-1) 7.96 (1.59) 7.62 (0.85) 14.0 (2.2) k (h-1) 0.562 (0.339) 0.820 (0.146) 0.741 (0.115) T1/2 (h) 1.64 (0.92) 0.86 (0.14) 0.95 (0.16) V0 (L kg-1) 0.43 (0.05) 0.49 (0.06) 1.31 (1.15) Vβ (L kg-1) - - 1.14 (0.09) Vmax (μg min-1) 9.08 (2.89) 6.09 (1.22) - Km (μg mL-1) 7.09 (1.35) 5.12 (1.19) -
References	[1]. Chandraratna RA. Tazarotene--first of a new generation of receptor-selective retinoids. Br J Dermatol. 1996;135 Suppl 49:18-25. [2]. Hsyu PH, et al. Pharmacokinetics of a novel retinoid AGN 190168 and its metabolite AGN 190299 after intravenous administration of AGN 190168 to rats. Biopharm Drug Dispos. 1994;15(5):347-357. [3]. Abramovits W, et al. Treatment of warty dyskeratoma with tazarotenic acid. J Am Acad Dermatol. 2002;46(2 Suppl Case Reports):S4.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	527.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₇NO₂S
Molecular Weight	323.409
Flash Point	272.9±30.1 °C
Exact Mass	323.097992
PSA	75.49000
LogP	4.95
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.671
InChIKey	IQIBKLWBVJPOQO-UHFFFAOYSA-N
SMILES	CC1(C)CCSc2ccc(C#Cc3ccc(C(=O)O)cn3)cc21
Storage condition	2-8°C

Synonyms

Tazarotenic Acid

3-Pyridinecarboxylic acid, 6-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-

6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylic acid

6-[(4,4-Dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinic acid

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