CAS 124-76-5|Isoborneol
| Common Name | Isoborneol | ||
|---|---|---|---|
| CAS Number | 124-76-5 | Molecular Weight | 154.249 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 212.0±0.0 °C at 760 mmHg |
| Molecular Formula | C10H18O | Melting Point | 208-214ºC |
| MSDS | ChineseUSA | Flash Point | 65.6±0.0 °C |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | DL-Isoborneol |
|---|---|
| Synonym | More Synonyms |
Isoborneol BiologicalActivity
| Description | Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 (HSV-1)[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>HSVResearch Areas >>InfectionResearch Areas >>Neurological Disease |
| Target | HSV-1 |
| In Vitro | Isoborneol ((±)-Isoborneol) protects against 6-OHDA-induced increases in caspase-3 activity and cytochrome C translocation into the cytosol from mitochondria. Isoborneol prevents 6-OHDA from decreasing the Bax/Bcl-2 ratio[1]. |
| References | [1]. Tian LL, Zhou Z, Zhang Q, et al. Protective effect of (+/-) isoborneol against 6-OHDA-induced apoptosis in SH-SY5Y cells. Cell Physiol Biochem. 2007;20(6):1019‐1032. [2]. Armaka M, Papanikolaou E, Sivropoulou A, Arsenakis M. Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1. Antiviral Res. 1999;43(2):79‐92. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 212.0±0.0 °C at 760 mmHg |
| Melting Point | 208-214ºC |
| Molecular Formula | C10H18O |
| Molecular Weight | 154.249 |
| Flash Point | 65.6±0.0 °C |
| Exact Mass | 154.135757 |
| PSA | 20.23000 |
| LogP | 2.71 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.502 |
| InChIKey | DTGKSKDOIYIVQL-ZCUBBSJVSA-N |
| SMILES | CC1(C)C2CCC1(C)C(O)C2 |
| Water Solubility | insoluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,531,1979 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,531,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03209
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,531,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0371 No. of Facilities: 1136 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 13463 (estimated) No. of Female Employees: 8811 (estimated)
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H228-H315 |
| Precautionary Statements | P210 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | F;Xi |
| Risk Phrases | R11 |
| Safety Phrases | S24/25 |
| RIDADR | UN1325 4.1/PG 2 |
| WGK Germany | 2 |
| RTECS | NP7300000 |
| Hazard Class | 4.1 |
| HS Code | 2906199090 |
Customs
| HS Code | 2906199090 |
|---|---|
| Summary | 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
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Synonyms
| Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1R,2S,4R)- |
| exo-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol |
| 2-Hydroxybornane |
| Borneol |
| )-Isoborneol |
| EINECS 204-712-4 |
| bornyl alcohol |
| Baros camphor |
| MFCD00074821 |
| endo-borneol |
| (1R,2S,4R)-(+)-Borneol |
| (+)-Bornyl alcohol |
| UNII:M89NIB437X |
| (1R,2S,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol |
| Bhimsaim camphor |
| d-borneol |
| 2-Hydroxycamphane |
| Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl- |
| 1,7,7-Trimethylbicyclo(2.2.1)heptan-2-ol |
| Dryobalanops camphor |
| Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl- |
| 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol |
| Borneo camphor |
| (1R,2S,4R)-borneol |
| (1R-endo)-1,7,7-Trimethylbicyclo(2.2.1)heptan-2-ol |
| Camphol |
| Camphane, 2-hydroxy- |
| Malayan camphor |
