Introduction：Basic information about CAS 19186-33-5|Aristeromycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Aristeromycin |
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| CAS Number | 19186-33-5 | Molecular Weight | 265.26900 |
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| Density | 1.92g/cm3 | Boiling Point | 595.1ºC at 760mmHg |
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| Molecular Formula | C11H15N5O3 | Melting Point | / |
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| MSDS | / | Flash Point | 313.7ºC |
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Names
| Name | Aristeromycin |
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| Synonym | More Synonyms |
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Aristeromycin BiologicalActivity
| Description | Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| Target | S-adenosylhomocysteine hydrolase[1] |
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| In Vitro | The IC50 value of Aristeromycin against AHCY is 38.5 nM at 50 μM SAH (approximately equal to the Km: 48 μM), but 271 nM at 1000 µM SAH (20× Km). With 60 min of preincubation, the mean IC50 value of Aristeromycin at 50 μM SAH is 12.7 nM[1]. Aristeromycin has IC50 values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth[1]. At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a[1]. |
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| References | [1]. Uchiyama N, et al. Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a. Eur J Pharmacol. 2017 Oct 5;812:138-146. [2]. Ishikura T, et al. Inhibition of S-adenosylhomocysteine hydrolase by purine nucleoside analogues. Nucleic Acids Symp Ser. 1983;(12):119-22. |
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Chemical & Physical Properties
| Density | 1.92g/cm3 |
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| Boiling Point | 595.1ºC at 760mmHg |
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| Molecular Formula | C11H15N5O3 |
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| Molecular Weight | 265.26900 |
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| Flash Point | 313.7ºC |
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| Exact Mass | 265.11700 |
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| PSA | 130.31000 |
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| Vapour Pressure | 5.19E-15mmHg at 25°C |
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| Index of Refraction | 1.881 |
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| InChIKey | UGRNVLGKAGREKS-GCXDCGAKSA-N |
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| SMILES | Nc1ncnc2c1ncn2C1CC(CO)C(O)C1O |
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| Storage condition | -20°C |
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Safety Information
| WGK Germany | 3 |
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| RTECS | GY4250000 |
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Synonyms
| Cycloadenosine |
| carbocyclic adenosine |
| 4'-O-Carbaadenosine |
