CAS 110-16-7|Maleic acid
Introduction：Basic information about CAS 110-16-7|Maleic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Maleic acid | ||
|---|---|---|---|
| CAS Number | 110-16-7 | Molecular Weight | 116.072 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 355.5±25.0 °C at 760 mmHg |
| Molecular Formula | C4H4O4 | Melting Point | 134-138ºC |
| MSDS | ChineseUSA | Flash Point | 183.0±19.7 °C |
| Symbol | GHS05, GHS07 | Signal Word | Danger |
Names
| Name | maleic acid |
|---|---|
| Synonym | More Synonyms |
Maleic acid BiologicalActivity
| Description | Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes. |
|---|---|
| Related Catalog | Natural Products >>Acids and AldehydesResearch Areas >>Infection |
| Target | Human Endogenous Metabolite GAD |
| In Vitro | The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal[2]. |
| References | [1]. Fonda ML, et al. Glutamate decarboxylase. Substrate specificity and inhibition by carboxylic acids. Biochemistry. 1972 Mar 28;11(7):1304-9. [2]. Paudyal R, et al. A novel approach in acidic disinfection through inhibition of acid resistance mechanisms; Maleic acid-mediated inhibition of glutamate decarboxylase activity enhances acid sensitivity of Listeria monocytogenes. Food Microbiol. 2018 Feb;69:96-104. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 355.5±25.0 °C at 760 mmHg |
| Melting Point | 134-138ºC |
| Molecular Formula | C4H4O4 |
| Molecular Weight | 116.072 |
| Flash Point | 183.0±19.7 °C |
| Exact Mass | 116.010956 |
| PSA | 74.60000 |
| LogP | -0.01 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.526 |
| InChIKey | VZCYOOQTPOCHFL-UPHRSURJSA-N |
| SMILES | O=C(O)C=CC(=O)O |
| Storage condition | Store at RT. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, bases. |
| Water Solubility | 790 g/L (25 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 708 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Gastrointestinal - ulceration or bleeding from stomach
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >720 mg/m3/1H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2400 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1560 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Fibroblast
- DOSE/DURATION :
- 20 mmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 183,89,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84505 No. of Facilities: 1840 (estimated) No. of Industries: 22 No. of Occupations: 27 No. of Employees: 17036 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84505 No. of Facilities: 2076 (estimated) No. of Industries: 36 No. of Occupations: 45 No. of Employees: 30064 (estimated) No. of Female Employees: 11590 (estimated)
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Fibroblast
- DOSE/DURATION :
- 20 mmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 183,89,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84505 No. of Facilities: 1840 (estimated) No. of Industries: 22 No. of Occupations: 27 No. of Employees: 17036 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84505 No. of Facilities: 2076 (estimated) No. of Industries: 36 No. of Occupations: 45 No. of Employees: 30064 (estimated) No. of Female Employees: 11590 (estimated)
Safety Information
| Symbol | GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302 + H312-H315-H317-H318-H335 |
| Precautionary Statements | P280-P301 + P312 + P330-P305 + P351 + P338 + P310 |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S28-S37 |
| RIDADR | UN 2215 |
| WGK Germany | 1 |
| RTECS | OM9625000 |
| Packaging Group | III |
| HS Code | 2917190090 |
Customs
| HS Code | 2917190090 |
|---|---|
| Summary | 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| (2Z)-2-Butenedioic acid |
| 2-Butenedioic acid, (2Z)- |
| cis-2-Butenedioic Acid |
| 2-Butenedioicacid (2Z)- |
| MFCD00063177 |
| EINECS 203-742-5 |
| Maleic acid |
| cis-Butenedioic acid,Toxilic acid |
| Maleic acid [NA2215] |
| (2Z)-But-2-enedioic acid |
