Introduction：Basic information about CAS 2169-44-0|lauroscholtzine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | lauroscholtzine |
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| CAS Number | 2169-44-0 | Molecular Weight | 341.401 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 506.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H23NO4 | Melting Point | 102.5°C |
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| MSDS | / | Flash Point | 259.9±30.1 °C |
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Names
| Name | (6aS)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-9-ol |
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| Synonym | More Synonyms |
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lauroscholtzine BiologicalActivity
| Description | Lauroscholtzine (N-Methyllaurotetanine), a natural alkaloid, is a 5-HT1A receptor agonist[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| References | [1]. Sudharshan Madapa, et al. Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors. J Nat Prod. 2015 Apr 24;78(4):722-9. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 506.1±50.0 °C at 760 mmHg |
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| Melting Point | 102.5°C |
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| Molecular Formula | C20H23NO4 |
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| Molecular Weight | 341.401 |
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| Flash Point | 259.9±30.1 °C |
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| Exact Mass | 341.162720 |
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| PSA | 51.16000 |
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| LogP | 3.09 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.604 |
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| InChIKey | ZFLRVRLYWHNAEC-AWEZNQCLSA-N |
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| SMILES | COc1cc2c(cc1O)CC1c3c(cc(OC)c(OC)c3-2)CCN1C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CE1057900
- CHEMICAL NAME :
- 6a-alpha-Aporphin-9-ol, 1,2,10-trimethoxy-
- CAS REGISTRY NUMBER :
- 2169-44-0
- LAST UPDATED :
- 198208
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C20-H23-N-O4
- MOLECULAR WEIGHT :
- 341.44
- WISWESSER LINE NOTATION :
- T C6666 1A Q KN&TT&J EO1 FQ K1 PO1 QO1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 170 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Rogersine |
| lauroscholtzine |
| 4H-Dibenzo[de,g]quinolin-9-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (6aS)- |
| N-Methyllaurotetanine |
| (6aS)-1,2,10-Trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-9-ol |
