CAS 59-51-8|DL-Methionine

Introduction：Basic information about CAS 59-51-8|DL-Methionine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. DL-Methionine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles307
8. Synonyms

Common Name	DL-Methionine
CAS Number	59-51-8	Molecular Weight	149.211
Density	1.2±0.1 g/cm3	Boiling Point	306.9±37.0 °C at 760 mmHg
Molecular Formula	C₅H₁₁NO₂S	Melting Point	270-273ºC
MSDS	ChineseUSA	Flash Point	139.4±26.5 °C

Names

Name	methionine
Synonym	More Synonyms

DL-Methionine BiologicalActivity

Description	DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills H. rostochiensis on potato plants[1][2][3].
Related Catalog	Research Areas >>InfectionResearch Areas >>Inflammation/Immunology
Target	H. rostochiensis[1]
In Vitro	The impact of DL-Methionine supplementation on animal performance interacts strongly with the crude protein (CP) content of the diet. Supplementation of DLM to a 20% crude protein diet for broilers reduces their abdominal fat weight, whereas this is not the case when the diet contained 23% CP. Breast meat yield is increased and abdominal fat content is decreased with increasing DL-Methionine supplementation, and this response is more pronounced in chickens reared on a diet with a lower protein level (20.5% CP) compared with a higher protein level (26%)[2].
In Vivo	DL-methionine significantly decreases the numbers of males, females, cysts and eggs of H. rostochiensis on potato plants. DL-methionine kills almost all the nematodes when applied 3 days after inoculation, and DL-methionine does not affect plant growth adversely[1].
References	[1]. K. evans, et al. Effects of amino acids on the reproduction of Heterodera rostochiensis. Nematologica, 1971, 17(4), 495-500. [2]. Swennen Q, et al. Effects of dietary protein content and 2-hydroxy-4-methylthiobutanoic acid or DL-methionine supplementation on performance and oxidative status of broiler chickens. Br J Nutr. 2011 Dec;106(12):1845-54. [3]. Garlich JD. Response of broilers to DL-methionine hydroxy analog free acid, DL-methionine, and L-methionine. Poult Sci. 1985 Aug;64(8):1541-8.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	306.9±37.0 °C at 760 mmHg
Melting Point	270-273ºC
Molecular Formula	C₅H₁₁NO₂S
Molecular Weight	149.211
Flash Point	139.4±26.5 °C
Exact Mass	149.051056
PSA	88.62000
LogP	0.37
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.531
InChIKey	FFEARJCKVFRZRR-UHFFFAOYSA-N
SMILES	CSCCC(N)C(=O)O
Storage condition	0-6°C
Stability	Stable. Incompatible with strong oxidising agents.
Water Solubility	1 M HCl: 0.5 M at 20 °C, clear, colorless \| 2.9 g/100 mL (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PD0456000

CHEMICAL NAME :: Methionine, DL-

CAS REGISTRY NUMBER :: 59-51-8

LAST UPDATED :: 199706

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C5-H11-N-O2-S

MOLECULAR WEIGHT :: 149.23

WISWESSER LINE NOTATION :: QV1YZ1S1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36 gm/kg/30D-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in leukocyte (WBC) count

REFERENCE :: JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 79,101,1963

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 gm/kg/13D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

REFERENCE :: JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 106,1714,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 39 gm/kg/20D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight

REFERENCE :: JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 106,1714,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - turkey

DOSE/DURATION :: 33600 mg/kg/4W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St., Champaign, IL 61820) V.1- 1921- Volume(issue)/page/year: 57,699,1978 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 gm/kg

SEX/DURATION :: female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 33,109,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3271 No. of Facilities: 1272 (estimated) No. of Industries: 5 No. of Occupations: 27 No. of Employees: 16781 (estimated) No. of Female Employees: 4397 (estimated)

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R33
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	PD0457000
HS Code	2930400000

Customs

HS Code	2930400000

Articles307

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Synonyms

Meonine

MFCD00063097

Metion

DL-2-Amino-4-(methylthio)butanoic acid

Neston

Urimeth

Metione

Dyprin

MET

Amurex

Cynaron

L-MET

EINECS 200-432-1

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