Introduction：Basic information about CAS 1433-11-0|Urea-d4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Urea-d4 is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
[2]. Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7.
[3]. Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 1519(11):20392.Wang H, et al. Urea. Subcell Biochem. 201473:7-29.
[4]. Wang H, et al. Urea. Subcell Biochem. 201473:7-29.
Chemical & Physical Properties
Density
1.212g/cm3
Boiling Point
196.6ºC at 760mmHg
Melting Point
132-135ºC(lit.)
Molecular Formula
CD4N2O
Molecular Weight
64.07990
Flash Point
72.7ºC
Exact Mass
64.05750
PSA
69.11000
LogP
0.42440
Vapour Pressure
0.395mmHg at 25°C
Index of Refraction
1.468
InChIKey
XSQUKJJJFZCRTK-JBISRTOLSA-N
SMILES
NC(N)=O
Safety Information
Personal Protective Equipment
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes
Xn
Risk Phrases
R40;R36/37/38
Safety Phrases
S24/25
RIDADR
NONH for all modes of transport
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