Introduction：Basic information about CAS 14365-45-8|9-(2-Deoxy-β-L-Ribofuranosyl)Adenine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 9-(2-Deoxy-β-L-Ribofuranosyl)Adenine |
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| CAS Number | 14365-45-8 | Molecular Weight | 251.24200 |
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| Density | 1.91g/cm3 | Boiling Point | 627.2ºC at 760 mmHg |
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| Molecular Formula | C10H13N5O3 | Melting Point | 186-187ºC |
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| MSDS | / | Flash Point | 333.1ºC |
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Names
| Name | 2'-Deoxy-L-adenosine |
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| Synonym | More Synonyms |
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9-(2-Deoxy-β-L-Ribofuranosyl)Adenine BiologicalActivity
| Description | 2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV)[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>HBV |
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| In Vitro | 2'-Deoxy-L-adenosine shows anti-hepadnavirus activity, withour affecting the replication of 15 other RNA and DNA viruses, neither nor inhibiting human DNA polymerases (α, β, and γ) or compromise mitochondrial function[1]. |
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| In Vivo | 2'-Deoxy-L-adenosine (p.o.; once daily) reduces viral load by as much as 108 genome equivalent/mL serum without drug-related toxicity in woodchuck efficacy model of chronic HBV infection[1]. |
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Chemical & Physical Properties
| Density | 1.91g/cm3 |
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| Boiling Point | 627.2ºC at 760 mmHg |
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| Melting Point | 186-187ºC |
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| Molecular Formula | C10H13N5O3 |
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| Molecular Weight | 251.24200 |
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| Flash Point | 333.1ºC |
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| Exact Mass | 251.10200 |
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| PSA | 119.31000 |
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| Vapour Pressure | 1.36E-16mmHg at 25°C |
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| Index of Refraction | 1.863 |
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| InChIKey | OLXZPDWKRNYJJZ-VQVTYTSYSA-N |
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| SMILES | Nc1ncnc2c1ncn2C1CC(O)C(CO)O1 |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2'-desoxyadenosine |
| 2'-Desoxy-adenosin |
| 2'-deoxy-adenosine |
