Introduction：Basic information about CAS 85416-75-7|(R)-(-)-Rolipram, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (R)-(-)-Rolipram |
|---|
| CAS Number | 85416-75-7 | Molecular Weight | 275.343 |
|---|
| Density | 1.2±0.1 g/cm3 | Boiling Point | 472.7±45.0 °C at 760 mmHg |
|---|
| Molecular Formula | C16H21NO3 | Melting Point | 134 °C |
|---|
| MSDS | / | Flash Point | 239.7±28.7 °C |
|---|
Names
| Name | (4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one |
|---|
| Synonym | More Synonyms |
|---|
(R)-(-)-Rolipram BiologicalActivity
| Description | (R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. |
|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Neurological Disease |
|---|
| In Vitro | The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMP hydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram (MedChem Express) suppresses caspase-1 cleavage and IL-1β secretion in a dose-dependent manner[1]. |
|---|
| References | [1]. Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944. |
|---|
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|
| Boiling Point | 472.7±45.0 °C at 760 mmHg |
|---|
| Melting Point | 134 °C |
|---|
| Molecular Formula | C16H21NO3 |
|---|
| Molecular Weight | 275.343 |
|---|
| Flash Point | 239.7±28.7 °C |
|---|
| Exact Mass | 275.152130 |
|---|
| PSA | 47.56000 |
|---|
| LogP | 1.43 |
|---|
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
|---|
| Index of Refraction | 1.552 |
|---|
| InChIKey | HJORMJIFDVBMOB-LBPRGKRZSA-N |
|---|
| SMILES | COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1 |
|---|
Safety Information
Customs
| HS Code | 2933790090 |
|---|
| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
|---|
Synonyms
| (-)-rolipram |
| (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |
| (R)-(-)-Rolipram |
| R-(-)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |
| 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)- |
| (R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one |
| (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one |
| 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)- |
| (S)-ROLIPRAM |
