CAS 85956-22-5|Pravastatin Lactone

Introduction：Basic information about CAS 85956-22-5|Pravastatin Lactone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NamePravastatin Lactone
CAS Number85956-22-5Molecular Weight406.51
Density1.2±0.1 g/cm3Boiling Point590.5±50.0 °C at 760 mmHg
Molecular FormulaC23H34O6Melting Point140-143ºC
MSDS/Flash Point199.5±23.6 °C

Names

Name[(1S,3S,7S,8S,8aR)-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
SynonymMore Synonyms

Pravastatin Lactone BiologicalActivity

DescriptionPravastatin lactone is a potent HMG-CoA inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis[1].
Related CatalogResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR)
References

[1]. Corsini A, et, al. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res. 1995 Jan;31(1):9-27.

Chemical & Physical Properties

Density1.2±0.1 g/cm3
Boiling Point590.5±50.0 °C at 760 mmHg
Melting Point140-143ºC
Molecular FormulaC23H34O6
Molecular Weight406.51
Flash Point199.5±23.6 °C
Exact Mass406.235535
PSA93.06000
LogP1.71
Vapour Pressure0.0±3.8 mmHg at 25°C
Index of Refraction1.548
InChIKeyOQARDMYXSOFTLN-PZAWKZKUSA-N
SMILESCCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C21

Synonyms

Butanoic acid, 2-methyl-, (1S,3S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3-hydroxy-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
[14C]-Pravastatin lactone
UNII:JBE3Z4192Q
Pravastatin lactone
Pravastatin sodium specified impurity D [EP]
pravastatin
UNII-JBE3Z4192Q
(1S,3S,7S,8S,8aR)-3-Hydroxy-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate
HMS2090H21
CAS 85955-36-8|S-2-Hydroxyethyl-D-cysteine
CAS 860011-60-5|2-AMINO-1H-IMIDAZOLE-4-CARBOXYLIC ACID
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