Introduction：Basic information about CAS 9007-81-2|freund's complete adjuvant, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | freund's complete adjuvant |
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| CAS Number | 9007-81-2 | Molecular Weight | 261.20700 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C9H12FN3O5 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-Amino-1-(β-D-arabinofuranosyl)-5-fluoro-2(1H)-pyrimidinone |
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freund's complete adjuvant BiologicalActivity
| Description | Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response[1][2]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Toll-like Receptor (TLR)Research Areas >>Inflammation/Immunology |
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| References | [1]. Fontes JA, et al. Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL-6 production during initiation of the immune response. Immun Inflamm Dis. 2017 Jun;5(2):163-176. [2]. Ji YW, et al. Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice. Nat Commun. 2023 Apr 17;14(1):2182. |
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Chemical & Physical Properties
| Molecular Formula | C9H12FN3O5 |
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| Molecular Weight | 261.20700 |
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| Exact Mass | 261.07600 |
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| PSA | 131.82000 |
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| Appearance of Characters | cell suspension | amber |
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| InChIKey | STRZQWQNZQMHQR-UHFFFAOYSA-N |
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| SMILES | Nc1nc(=O)n(C2OC(CO)C(O)C2O)cc1F |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- LS6860000
- CHEMICAL NAME :
- Freund's adjuvant
- CAS REGISTRY NUMBER :
- 9007-81-2
- LAST UPDATED :
- 199504
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 14,147,1967 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4888 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated)
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Safety Information
| Safety Phrases | 23-24/25 |
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| WGK Germany | 3 |
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| RTECS | LS6860000 |
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| HS Code | 3822009000 |
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Customs
