Introduction：Basic information about CAS 203784-52-5|Nortriptyline-d3 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nortriptyline-d3 hydrochloride |
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| CAS Number | 203784-52-5 | Molecular Weight | 302.856 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C19H19ClD3N | Melting Point | 213-215ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N-(trideuteriomethyl)propan-1-amine,hydrochloride |
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| Synonym | More Synonyms |
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Nortriptyline-d3 hydrochloride BiologicalActivity
| Description | Nortriptyline-d3 (Desmethylamitriptyline-d3) hydrochloride is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Neurological Disease |
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| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
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| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23. |
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Chemical & Physical Properties
| Melting Point | 213-215ºC |
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| Molecular Formula | C19H19ClD3N |
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| Molecular Weight | 302.856 |
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| Exact Mass | 302.162903 |
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| PSA | 12.03000 |
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| LogP | 5.01930 |
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| InChIKey | SHAYBENGXDALFF-NIIDSAIPSA-N |
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| SMILES | CNCCC=C1c2ccccc2CCc2ccccc21.Cl |
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Synonyms
| Nortrilen-d3 |
| Pamelor-d3 |
| Norzepine-d3 |
| Nortriptyline-d3 Hydrochloride |
| Allegron-d3 |
| 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(H)methyl-1-propanamine hydrochloride (1:1) |
| Acetexa-d3 |
| Sensival-d3 |
| 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(H)methylpropan-1-amine hydrochloride (1:1) |
| Vividyl-d3 |
| 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-(methyl-d)-, hydrochloride (1:1) |
