CAS 1204401-49-9|WQ 1

Introduction：Basic information about CAS 1204401-49-9|WQ 1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameWQ 1
CAS Number1204401-49-9Molecular Weight337.47800
Density/Boiling Point/
Molecular FormulaC21H23NOSMelting Point/
MSDS/Flash Point/

Names

Name2-(1-Benzyl-4-piperidinyl)-2,3-dihydro-4H-thiochromen-4-one

WQ 1 BiologicalActivity

Descriptionσ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells[1].
Related CatalogResearch Areas >>CancerResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Sigma Receptor
In Vitroσ1 Receptor antagonist-1 (compound 9) (10 μM; 48 hours) inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells[1]. Cell Cycle Analysis[1] Cell Line: MCF-7/ADR, MCF-7 cells Concentration: 10 μM Incubation Time: 48 hours Result: Increased the number of cells in G0/G1 (27.8%) and decreased those in S phase (46.7%), in a sigma 1-dependent manner. It selectively affects the high sigma 1 receptor expressing MCF-7/ADR but not the low sigma 1 receptor expressing MCF-7 cells.
In VivoPretreatment withσ1 Receptor antagonist-1 (1 mg/kg; s.c.) significantly increases the anti-nociceptive effect produces by morphine over the entire time course starting at 60 min[1]. Animal Model: Male CD-1 mice[1] Dosage: 1 mg/kg Administration: S.c. Result: Significantly increased the anti-nociceptive effect produced by morphine over the entire time course starting at 60 min.
References

[1]. Piergentili A, et al. Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J Med Chem. 2010;53(3):1261-1269.

Chemical & Physical Properties

Molecular FormulaC21H23NOS
Molecular Weight337.47800
Exact Mass337.15000
PSA45.61000
LogP4.58380
InChIKeyXWMHOCDNGHEUMF-UHFFFAOYSA-N
SMILESO=C1CC(C2CCN(Cc3ccccc3)CC2)Sc2ccccc21

Safety Information

HS Code2934999090

Customs

HS Code2934999090
Summary2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
CAS 1038549-82-4|3,4-Dimethoxy-N-[3-(1,2,3,4-tetrahydro-7-isoquinolinylcarbamoyl)b enzyl]benz
CAS 883872-01-3|4,6-Bis(benzylsulfanyl)-2-(methylsulfanyl)-5-pyrimidinecarboxylic acid
Recommended......
CAS 128277-24-7|4-CHLORO-2-PYR CAS 128133-59-5|1-(Benzyloxy)- CAS 120-95-6|2,4-Di-tert-penty CAS 125656-83-9|9-Methoxy-1,3- CAS 12068-51-8|magnesium alumi CAS 12037-42-2|vanadium oxide CAS 126162-38-7|4-Cyano-2,3-di CAS 122066-43-7|1,3-Adamantane CAS 128538-82-9|3,3-DICHLORO-2 CAS 124389-14-6|4-(11-Hydroxyu CAS 12223-39-1|Disperse Red 72 CAS 125662-60-4|4-Sulfo-2,3,5, CAS 123333-60-8|Sulfuricacid, CAS 126689-01-8|Cyclopropylbor CAS 124289-21-0|3-Bromo-5-meth CAS 126378-42-5|4-methoxy-3-(t CAS 129779-30-2|tert-butyl 3,5 CAS 121495-40-7|2-(2-N-BOC-N-M CAS 120811-33-8|N-methyloxan-3 CAS 121-28-8|Ethanone,1-(3,4-d
Disclaimer

This site is a non-commercial website, not accept any sponsorship and advertising. The content is collated from the Internet, does not represent the position of this site, for personal reference only, please distinguish by yourself! The belongs to the original author.

Copyright © 2025 All Rights Reserved.

TOP