CAS 959705-64-7|TC-E 5005
Introduction：Basic information about CAS 959705-64-7|TC-E 5005, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | TC-E 5005 | ||
|---|---|---|---|
| CAS Number | 959705-64-7 | Molecular Weight | 270.33000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C15H18N4O | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazin e |
|---|---|
| Synonym | More Synonyms |
TC-E 5005 BiologicalActivity
| Description | TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 values of 7.28, 239, 779, 919, 3,100, and 3,700 nM for PDE10A, 2A, 11A, 5A, 7B and 3A, respectively. TC-E 5005 inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Metabolic Disease |
| Target | PDE10A:7.28 nM (IC50) PDE2A:239 nM (IC50) hPDE11A:779 nM (IC50) PDE5A:919 nM (IC50) PDE7B:3100 nM (IC50) PDE3A:3700 nM (IC50) |
| In Vitro | TC-E 5005 (500 nM) inhibits norepinephrine or phenylephrine and EFS (electric field stimulation)-induced contraction of human prostate strips[1]. TC-E 5005 (500 nM) shows amplification of treprostinil-induced relaxations, which were significant from 0.03 to 30 μM treprostinil[1]. |
| References | [1]. Hennenberg M, et al. Inhibition of Adrenergic and Non-Adrenergic Smooth Muscle Contraction in the Human Prostate by the Phosphodiesterase 10-Selective Inhibitor TC-E 5005. Prostate. 2016 Nov;76(15):1364-74. |
Chemical & Physical Properties
| Molecular Formula | C15H18N4O |
|---|---|
| Molecular Weight | 270.33000 |
| Exact Mass | 270.14800 |
| PSA | 52.31000 |
| LogP | 2.85540 |
| InChIKey | YNADXFWEXJTQSZ-UHFFFAOYSA-N |
| SMILES | CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12 |
Synonyms
| TC-E 5005 |
