CAS 839713-36-9|Nelotanserin
Introduction：Basic information about CAS 839713-36-9|Nelotanserin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nelotanserin | ||
|---|---|---|---|
| CAS Number | 839713-36-9 | Molecular Weight | 437.23800 |
| Density | 1.55 g/cm3 | Boiling Point | 425.886ºC at 760 mmHg |
| Molecular Formula | C18H15BrF2N4O2 | Melting Point | / |
| MSDS | / | Flash Point | 211.369ºC |
Names
| Name | 1-[3-(4-bromo-2-methylpyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea |
|---|---|
| Synonym | More Synonyms |
Nelotanserin BiologicalActivity
| Description | Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorResearch Areas >>Neurological DiseaseResearch Areas >>Cancer |
| Target | 5-HT2A Receptor:1.7 nM (IC50) 5-HT2C Receptor:79 nM (IC50) 5-HT2B Receptor:791 nM (IC50) |
| In Vitro | Results from IP accumulation assays suggest that Nelotanserin is a potent 5-HT2A full inverse agonist (IC50=1.7 nM), a moderately potent 5-HT2C partial inverse agonist (IC50=79 nM) (maximal response was 62% of the response obtained for the reference inverse agonist clozapine), and a weak 5-HT2B inverse agonist (IC50=791 nM). Nelotanserin displays high affinity for recombinant human 5-HT2A receptors (Ki=0.35 nM), moderate affinity for human 5-HT2C receptors (Ki=100 nM), and low affinity for human 5-HT2B receptors (2000 nM) stably expressed in HEK293 cells. The results suggest that Nelotanserin has a 262-fold higher affinity for human 5-HT2A than 5-HT2C receptors and a 6610-fold higher affinity for human 5-HT2A than 5-HT2B receptors[1]. |
| In Vivo | Each compound is tested in a minimum of five rats by oral gavage with administration occurring in the middle of the inactive period, 6 h after light onset. The delta power during non-REM sleep (NREMS) is significantly different between all the analogues tested and the vehicle control. Nelotanserin (Compound 39) produces significant increases in delta power that persist for the first 4 h following dosing. Significant differences are found, however, in NREMS bout length. Nelotanserin significantly increases NREMS bout length during the first hour following dosing, and 3 does so during the second hour. In conjunction with this increased NREM bout duration, the number of NREM bouts decrease during the first hour for Nelotanserin (p<0.01) as well as for compound 15 (p<0.05)[2]. |
| References | [1]. Al-Shamma HA et al. Nelotanserin, a novel selective human 5-hydroxytryptamine2A inverse agonist for the treatment of insomnia. J Pharmacol Exp Ther. 2010 Jan;332(1):281-90. [2]. Teegarden BR et al. Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia. J Med Chem. 2010 Mar 11;53(5):1923-36. |
Chemical & Physical Properties
| Density | 1.55 g/cm3 |
|---|---|
| Boiling Point | 425.886ºC at 760 mmHg |
| Molecular Formula | C18H15BrF2N4O2 |
| Molecular Weight | 437.23800 |
| Flash Point | 211.369ºC |
| Exact Mass | 436.03500 |
| PSA | 71.67000 |
| LogP | 4.86700 |
| InChIKey | COSPVUFTLGQDQL-UHFFFAOYSA-N |
| SMILES | COc1ccc(NC(=O)Nc2ccc(F)cc2F)cc1-c1c(Br)cnn1C |
| Storage condition | 2-8℃ |
Synonyms
| UNII-4ZA73QEW2P |
| Nelotanserin |
| APD125 |
